In vivo comparison of the biocompatibility of two root canal sealers implanted into the subcutaneous connective tissue of rats

Journal of Endodontics
I KolokourisI Vlemmas

Abstract

The purpose of this study was to evaluate the in vivo biocompatibility of Apexit (a calcium hydroxide) and Pulp Canal Sealer (a classic zinc oxide-eugenol), root canal sealers, after implantation in rat connective tissue. Forty-four white female Wistar-Furth rats were used. Each sealer was placed in Teflon tubes and implanted into specific dorsal subdermal tissues sites. Implants were removed after 5, 15, 60, and 120 days; fixed; and histologically prepared for microscopical evaluation. Severe inflammatory reactions with differing extensions of necrosis were observed with Apexit on the 5th and 15th days. The intensity of the reaction had diminished by the 60th day, and this reduction continued progressively through the 120th day. It was characterized by the presence of connective tissue with a few macrophages. Moderate to severe inflammation with confined areas of necrosis was observed in the Pulp Canal Sealer specimens on the 5th day. The intensity of the reaction diminished by the 15th, 60th, and 120th days, but remained slightly greater than Apexit through longterm observation periods.

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Citations

Sep 1, 2005·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Jalil ModaresiShokufeh Shahrabi
Apr 19, 2003·International Endodontic Journal·M Bernáth, J Szabó
May 4, 2011·International Endodontic Journal·Z Mohammadi, P M H Dummer
Oct 15, 2013·Microscopy Research and Technique·Karen Melina TrichêsLuiz Pascoal Vansan
Aug 30, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Dalia Mukhtar-Fayyad
Aug 3, 2001·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·W Geurtsen
Mar 26, 2011·Journal of Applied Oral Science : Revista FOB·Fabiana Soares GreccaJosé Antônio Poli de Figueiredo
Sep 22, 2010·Journal of Applied Oral Science : Revista FOB·Samira Esteves Afonso CamargoCarlos Henrique Ribeiro Camargo
Feb 27, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Edilson José ZafalonPaula Dechichi
Jun 25, 2008·Expert Review of Medical Devices·Bénédicte EnkelPierre Weiss
Feb 10, 2011·Materials·Rubens M FreitasElcio Marcantonio
Dec 10, 2002·Journal of Endodontics·T SchwarzeW Geurtsen
Dec 10, 2002·Journal of Endodontics·T SchwarzeW Geurtsen
Nov 23, 2006·Journal of Biomedical Materials Research. Part a·Renata F C BatistaCiomar A Bersani-Amado
Aug 21, 2003·Journal of Cellular and Molecular Medicine·R L De Oliveira MusselC A Mandarim-De-Lacerda
Apr 25, 2014·Applied Microbiology and Biotechnology·Somnath Roy, Narayanannair Muraleedharan
Jun 29, 2004·Journal of Endodontics·Saud Al-AwadhiLynne A Opperman
Apr 27, 2011·Brazilian Dental Journal·Camila Maggi Maia SilveiraGibson Luiz Pilatti
Mar 1, 2003·Journal of Applied Oral Science : Revista FOB·Maria Renata Giazzi NassriAntonio Carlos Bombana
Mar 28, 2020·Dental Materials Journal·Takashi KomabayashiYohji Imai
Dec 19, 2018·Journal of Endodontics·Christin Michelle GiacominoAnibal Diogenes

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