Abstract
To analyze the density and morphology of corneal epithelial cells and keratocytes by in vivo confocal microscopy (IVCM) in patients with herpes zoster ophthalmicus (HZO) as associated with corneal innervation. Prospective, controlled and masked cross-sectional study. setting: Single-center study. Thirty eyes with the diagnosis HZO and their contralateral clinically unaffected eyes, 15 eyes of 15 normal controls. intervention procedures: In vivo confocal microscopy and corneal esthesiometry of the central cornea. Changes in morphology and density of the superficial and basal epithelial cells and stromal keratocytes, and correlation with corneal sensation. The density of superficial epithelial cells in HZO eyes with severe sensation loss (766.5 ± 25.2 cells/mm(2)) was significantly lower than both healthy control eyes (1450.23 ± 150.83 cells/mm(2)) and contralateral unaffected eyes (1974.13 ± 298.24 cells/mm(2)) (P = .003). Superficial epithelial cell size (1162.5 μm(2)) was significantly larger in HZO eyes with severe loss of sensation, as compared to contralateral (441.46 ± 298.14) or healthy eyes (407.4 ± 47.2μm(2); all P < .05). The density of basal epithelial cells, anterior keratocytes, and posterior keratocytes did not sho...Continue Reading
References
Jul 1, 1980·Experimental Neurology·R W Beuerman, B Schimmelpfennig
Apr 1, 1995·Ophthalmology·W WiegandA J Garcia
Nov 1, 1994·Experimental Eye Research·J Garcia-HirschfeldC Belmonte
Jul 13, 2000·Ophthalmology·S BoniniL Aloe
May 3, 2001·Cornea·L Oliveira-Soto, N Efron
Mar 28, 2002·Cornea·Maria E RosenbergMinna H Vesaluoma
Feb 27, 2003·Progress in Retinal and Eye Research·Katsuyoshi SuzukiTeruo Nishida
Aug 25, 2004·Investigative Ophthalmology & Visual Science·José M Benítez del CastilloJulian Garcia-Sanchez
Apr 10, 2007·Ophthalmology·Eric E GabisonThanh Hoang-Xuan
Feb 14, 2008·Ophthalmology·Stephen C Kaufman
Feb 14, 2008·Ophthalmology·Thomas J Liesegang
May 5, 2009·Cornea·Liza S VeraMarc Muraine
Jul 4, 2009·Cornea·Dipika V PatelCharles N J McGhee
Sep 12, 2009·Ophthalmology·Toine HillenaarLies Remeijer
Feb 19, 2010·Cornea·Antoine LabbéChristophe Baudouin
Apr 9, 2010·Investigative Ophthalmology & Visual Science·Juana GallarCarlos Belmonte
Sep 3, 2010·Ophthalmology·Pedram HamrahDeborah Pavan-Langston
Nov 13, 2010·Investigative Ophthalmology & Visual Science·Giulio FerrariReza Dana
Dec 15, 2010·Ophthalmology·Xiaobo ZhangFan Lu
Dec 21, 2010·American Journal of Ophthalmology·Thaer S AlomarHarminder S Dua
Jul 2, 2011·Clinical & Experimental Ophthalmology·Marine HovakimyanOliver Stachs
Aug 11, 2011·Japanese Journal of Ophthalmology·Daisuke NagasatoMurat Dogru
May 23, 2012·Ophthalmology·Pedram HamrahDeborah Pavan-Langston
Sep 25, 2012·Ophthalmology·Pedram HamrahDeborah Pavan-Langston
Aug 24, 2013·PloS One·Takefumi YamaguchiPedram Hamrah
Citations
Feb 16, 2016·Survey of Ophthalmology·Bradley J Katz, Kathleen B Digre
Jul 19, 2015·American Journal of Ophthalmology·Mehmet Cem Mocan, Murat Irkec
Jul 19, 2015·American Journal of Ophthalmology·Pedram HamrahDeborah Pavan-Langston
Sep 27, 2018·Scientific Reports·Yu-Tung ChenSheng-Lung Huang
May 23, 2020·Experimental Eye Research·Gary H F YamVishal Jhanji
Apr 2, 2021·Ocular Immunology and Inflammation·Radhika ThundikandyRathinam Sr
Aug 19, 2021·The Ocular Surface·Stephanie M CoxPedram Hamrah