In Vivo confocal microscopic changes of the corneal epithelium and stroma in patients with herpes zoster ophthalmicus

American Journal of Ophthalmology
Pedram HamrahDeborah Pavan-Langston

Abstract

To analyze the density and morphology of corneal epithelial cells and keratocytes by in vivo confocal microscopy (IVCM) in patients with herpes zoster ophthalmicus (HZO) as associated with corneal innervation. Prospective, controlled and masked cross-sectional study. setting: Single-center study. Thirty eyes with the diagnosis HZO and their contralateral clinically unaffected eyes, 15 eyes of 15 normal controls. intervention procedures: In vivo confocal microscopy and corneal esthesiometry of the central cornea. Changes in morphology and density of the superficial and basal epithelial cells and stromal keratocytes, and correlation with corneal sensation. The density of superficial epithelial cells in HZO eyes with severe sensation loss (766.5 ± 25.2 cells/mm(2)) was significantly lower than both healthy control eyes (1450.23 ± 150.83 cells/mm(2)) and contralateral unaffected eyes (1974.13 ± 298.24 cells/mm(2)) (P = .003). Superficial epithelial cell size (1162.5 μm(2)) was significantly larger in HZO eyes with severe loss of sensation, as compared to contralateral (441.46 ± 298.14) or healthy eyes (407.4 ± 47.2μm(2); all P < .05). The density of basal epithelial cells, anterior keratocytes, and posterior keratocytes did not sho...Continue Reading

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Citations

Feb 16, 2016·Survey of Ophthalmology·Bradley J Katz, Kathleen B Digre
Jul 19, 2015·American Journal of Ophthalmology·Mehmet Cem Mocan, Murat Irkec
Jul 19, 2015·American Journal of Ophthalmology·Pedram HamrahDeborah Pavan-Langston
May 23, 2020·Experimental Eye Research·Gary H F YamVishal Jhanji
Apr 2, 2021·Ocular Immunology and Inflammation·Radhika ThundikandyRathinam Sr

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