In Vivo Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease

Journal of Ophthalmology
Yasuhito IkegawaYuichi Ohashi

Abstract

To compare the morphology of two types of vortex keratopathy: amiodarone-induced keratopathy and the Fabry disease-associated keratopathy. Eight patients who were receiving oral amiodarone therapy and 3 patients with Fabry disease, a mother and her 2 daughters, were examined by slit-lamp biomicroscopy and in vivo confocal microscopy (IVCM) regularly. Amiodarone-induced keratopathy developed in 7 of the 8 patients, and it was detected as early as 7 days by IVCM and 14 days by slit-lamp biomicroscopy. The in vivo confocal microscopic images showed a clustering of corneal epithelial cells with a highly reflective cytoplasm in both types of keratopathy. In the amiodarone-induced keratopathy, the highly reflective epithelial cells were first found at the center of the cornea and then spread to the periphery with increasing time on amiodarone. In Fabry disease, the highly reflective epithelial cells were consistently observed extending from the limbus to the central cornea. These findings suggest that the corneal epithelial cells most likely endocytose amiodarone from the tear film in the amiodarone-induced keratopathy. In Fabry disease, globotriaosylceramide deposits are taken up by the lysosomes of the limbal epithelial stem cells,...Continue Reading

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Citations

Nov 2, 2019·The British Journal of Ophthalmology·Melanie D Sivley, William J Benjamin
Jun 27, 2020·European Journal of Ophthalmology·Matteo PrencipeGiovanna Gabbriellini
May 25, 2021·American Journal of Ophthalmology Case Reports·Hidenori InoueAtsushi Shiraishi
Aug 20, 2021·Vestnik oftalmologii·D S IsmailovaA S Moiseev

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

IVCM

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