PMID: 11912354Mar 26, 2002Paper

In vivo confocal microscopy in primary congenital glaucoma with megalocornea

Journal of Glaucoma
Leornardo MastropasquaE Doronzo

Abstract

To report the microscopic findings of congenital glaucoma-related megalocornea using in vivo confocal microscopy. Two consecutive adult patients presenting the typical features of glaucomatous megalocornea underwent a complete ophthalmologic examination. The first patient presented with progressive glaucoma with bilateral megalocornea. The second patient's left eye was affected by megalocornea without actual evidence of glaucoma, whereas the right eye was healthy. Both patients were examined using a new-generation scanning slit corneal confocal microscope. In both patients, confocal microscopy revealed a mild reduction of keratocyte density in the mid and rear stroma, a particular abnormal "clew-shaped" morphology of stromal nerves, and the presence of discontinuous hyperreflective structures overhanging the endothelial layer at the level of the Descemet membrane. The endothelium showed severe polymegethism, pleomorphism, and a markedly decreased cell density, and focal cellular lesions were noted. Confocal microscopy is a diagnostic tool used to evaluate microscopic aspects of Haab striae and endothelial morphologic changes in glaucomatous megalocornea. Unsuspected alterations, such as nerves abnormalities and focal endothelia...Continue Reading

References

Sep 1, 1991·Ophthalmic Paediatrics and Genetics·F M MeireJ W Delleman
Feb 1, 1990·Archives of Ophthalmology·P NucciS K Shevell
Feb 1, 1989·Australian and New Zealand Journal of Ophthalmology·P Lockie, J Elder
Jun 1, 1984·Acta Ophthalmologica·A Pollack, M Oliver
Jan 1, 1983·Archives of Ophthalmology·G L SkutaE S Ericson
Oct 1, 1996·Journal of Medical Genetics·I BarisićL Zergollern
Oct 2, 1998·Cornea·R K MustonenC K Kim
Jul 1, 1999·Current Opinion in Ophthalmology·W M PetrollJ V Jester
Sep 15, 1999·Ophthalmology·L P WernerG Renard

❮ Previous
Next ❯

Citations

Nov 15, 2006·Cornea·Tamara Wygnanski-Jaffe, Irina S Barequet
Jan 25, 2003·The British Journal of Ophthalmology·I JalbertM Coroneo
Dec 25, 2003·The British Journal of Ophthalmology·S SrinivasanF Roberts
May 25, 2012·Middle East African Journal of Ophthalmology·Heidar AminiRamin Daneshvar
Jan 31, 2012·Journal français d'ophtalmologie·M Boulze-PankertD Denis
Oct 17, 2015·Journal of Pediatric Ophthalmology and Strabismus·Oriel SpiererTa C Chang
Nov 3, 2015·Journal français d'ophtalmologie·A AzizD Denis
Jun 1, 2006·Journal of Microscopy·Emily C RothsteinRobert S Balaban
Sep 4, 2012·Acta Ophthalmologica·Zisis GatzioufasBerthold Seitz
Oct 16, 2015·Indian Journal of Ophthalmology·Gaurav SanghiAshish Ahuja
Sep 5, 2006·Survey of Ophthalmology·Auguste G-Y ChiouRoger W Beuerman
Mar 28, 2006·American Journal of Ophthalmology·Leonardo MastropasquaMarco Ciancaglini
Oct 31, 2013·Seminars in Ophthalmology·George D KymionisIoannis G Pallikaris
Feb 1, 2017·Acta Ophthalmologica·Azadeh DoozandehMehdi Yasseri
May 1, 2004·Journal of Glaucoma·Marta Junqueira HenriquesRemo Susanna
Nov 16, 2006·Journal of Glaucoma·Tak Yee Tania TaiJody R Piltz-Seymour
Mar 1, 2014·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Leonardo MastropasquaMarco Ciancaglini
Sep 15, 2020·Cornea·Shikha GuptaViney Gupta
Apr 23, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yun HsiaJehn-Yu Huang
Apr 7, 2007·Journal of Pediatric Ophthalmology and Strabismus·João E LopesWilliam C Steinmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.