In vivo confocal microscopy of inflammatory cells in the corneal subbasal nerve plexus in patients with different subtypes of anterior uveitis

The British Journal of Ophthalmology
Andreea S PostoleFriederike Mackensen

Abstract

Previously we could show increased numbers and densities of dendritic-like cells (DLCs) in the subbasal nerve plexus of the central cornea in patients with herpetic anterior uveitis (HAU). Now we aimed to explore these and other inflammatory cells seen in this layer in different subtypes of anterior uveitis using in vivo confocal microscopy. Consecutive eyes of patients with different types of anterior uveitis, HAU, Fuchs' uveitis syndrome (FUS), juvenile idiopathic arthritis (JIA) and human leucocyte antigen (HLA)-B27-related anterior uveitis were examined in vivo with the combination of Heidelberg Retina Tomograph II/III and Rostock Cornea Module. The contralateral eye was used as control. Inflammatory cells were defined on the basis of their morphology: type 1 (DLCs) and type 2 (cell bodies lacking dendrites). Frequencies were evaluated statistically in each group. The difference between means of type 1 cells density of affected eyes in all four groups was significant (one-way analysis of variance (ANOVA) p=0.039). The difference between means of type 1 cell densities of affected eyes in patients with HAU (96.8±44.2 cells/mm(2), n=10) and that of patients with FUS (46.4±38.7 cells/mm(2), n=17) was significant (Tukey's post h...Continue Reading

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Citations

Jul 12, 2017·Ocular Immunology and Inflammation·Jay SiakSoon-Phaik Chee
Mar 5, 2019·Vestnik oftalmologii·S E AvetisovA L Sidamonidze
Apr 15, 2018·International Ophthalmology·T FioreC Cagini
Oct 26, 2018·The British Journal of Ophthalmology·Scott HauDaniel F P Larkin
Oct 1, 2019·International Ophthalmology Clinics·K Matthew McKay, Deborah S Jacobs
Feb 29, 2020·International Ophthalmology·Dimitrios KalogeropoulosChris Kalogeropoulos
Oct 26, 2018·Investigative Ophthalmology & Visual Science·Chan-Wei NienShun-Fa Yang
Dec 29, 2020·Frontiers in Cellular Neuroscience·Adrian Guerrero-MorenoAnnabelle Réaux-Le Goazigo
Jul 10, 2021·Clinical & Experimental Ophthalmology·Holly R ChinneryLaura E Downie

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