In vivo cross-protection to African horse sickness Serotypes 5 and 9 after vaccination with Serotypes 8 and 6

Vaccine
Beate F von TeichmanTheresa K Smit

Abstract

The polyvalent African horsesickness (AHS) attenuated live virus (AHS-ALV) vaccine produced at Onderstepoort Biological Products incorporates 7 of the 9 known serotypes circulating in southern Africa. Serological cross-reaction has been shown in vitro to Serotypes 5 and 9 by Serotypes 8 and 6 respectively, but the degree of in vivo cross-protection between these serotypes in vaccinated horses has not previously been reported. Due to the increasing incidence of AHS Serotypes 5 and 9 in the field, over the last 3-4 seasons of AHS in South Africa, and the absence of Serotypes 5 and 9 in the AHS-ALV vaccine, it was necessary to conduct a vaccination-challenge study to determine in vivo cross-protection of vaccine-incorporated Serotypes 8 and 6 respectively. Groups of horses were vaccinated with either the polyvalent AHS-ALV vaccine or a monovalent Serotype 6 (vAHSV6) or 8 (vAHSV8) vaccine to determine the cross-protection of vaccinated horses following challenge with virulent AHS virus (AHSV) of either Serotype 5, 6, 8 or 9. Serial vaccination of naive horses with the polyvalent AHS-ALV vaccine generated a broad neutralizing antibody response to all vaccine strains as well as cross-neutralizing antibodies to Serotypes 5 and 9. Boos...Continue Reading

References

Nov 1, 1988·Tropical Animal Health and Production·N K Blackburn, R Swanepoel
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Sep 20, 2001·The Journal of General Virology·J L Martínez-TorrecuadradaJ I Casal

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Citations

Apr 12, 2014·PloS One·Katarzyna Bachanek-BankowskaPeter P C Mertens
Dec 22, 2015·Virus Research·Sonja MareeJacques Theron
Apr 20, 2016·Transboundary and Emerging Diseases·A Sánchez-MatamorosJ M Sánchez-Vizcaíno
Oct 13, 2018·Veterinary Research·Susan J DennisEdward P Rybicki
Jul 22, 2019·Viruses·Harry G NgoveniJ J Otto Koekemoer
Jul 9, 2020·Veterinary World·Umberto MoliniNicola D'Alterio
Dec 5, 2019·BMC Veterinary Research·Daria A RutkowskaMartha M O'Kennedy
Jul 14, 2020·Current Opinion in Virology·Eva Calvo-PinillaJavier Ortego

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