In vivo degradation of magnesium plate/screw osteosynthesis implant systems: Soft and hard tissue response in a calvarial model in miniature pigs

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Benoit SchallerT Iizuka

Abstract

Biodegradable magnesium plate/screw osteosynthesis systems were implanted on the frontal bone of adult miniature pigs. The chosen implant geometries were based on existing titanium systems used for the treatment of facial fractures. The aim of this study was to evaluate the in vivo degradation and tissue response of the magnesium alloy WE43 with and without a plasma electrolytic surface coating. Of 14 animals, 6 received magnesium implants with surface modification (coated), 6 without surface modification (uncoated), and 2 titanium implants. Radiological examination of the skull was performed at 1, 4, and 8 weeks post-implantation. After euthanasia at 12 and 24 weeks, X-ray, computed tomography, and microfocus computed tomography analyses and histological and histomorphological examinations of the bone/implant blocks were performed. The results showed a good tolerance of the plate/screw system without wound healing disturbance. In the radiological examination, gas pocket formation was found mainly around the uncoated plates 4 weeks after surgery. The micro-CT and histological analyses showed significantly lower corrosion rates and increased bone density and bone implant contact area around the coated screws compared to the unco...Continue Reading

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Citations

Feb 9, 2019·Journal of Biomaterials Applications·Narumi OshibeHiroyuki Harada
May 10, 2019·Biomaterials Science·Mehdi Razavi, Yan Huang
Feb 16, 2017·Neural Regeneration Research·Bo-Han LiXiao Wang
May 1, 2018·Science and Technology of Advanced Materials·Yu-Kyoung KimMin-Ho Lee
Dec 12, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Usman RiazWaseem Haider
Jul 18, 2017·Journal of Materials Science. Materials in Medicine·Hendrik NaujokatYahya Açil
Nov 3, 2020·Advanced Healthcare Materials·Matthew Simon DarguschRachel Allavena
Feb 6, 2018·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Andrea TorroniPaulo G Coelho
Jul 20, 2021·Analytical Chemistry·Michael E SmithWilliam R Heineman

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