In Vivo Delivery of Nitric Oxide-Sensing, Single-Walled Carbon Nanotubes

Current Protocols in Chemical Biology
Nicole M IversonGerald N Wogan

Abstract

Detection of nitric oxide (NO) in vivo by single-walled carbon nanotubes (SWNT) is based on the fluorescent properties of SWNT and the ability of NO to quench the fluorescence signal. Alterations of the signal can be utilized to detect a small molecule in vivo that has not previously been possible by other assay techniques. The protocols described here explain the techniques used to prepare NO-detecting SWNTs and to administer them to mice by both intravenous and subcutaneous routes. These techniques can also be utilized with other SWNT sensors as well as non-SWNT sensors.

Citations

Feb 15, 2017·Analytica Chimica Acta·Eliana F C SimõesJoaquim C G Esteves da Silva
May 24, 2018·Journal of Molecular Endocrinology·Pierre PoinsotFrançois Leulier
May 19, 2017·Disaster Medicine and Public Health Preparedness·Matthew John WatermeyerAbdullah Ebrahim Laher
Jul 12, 2019·Cancer Research·Santanu BhattacharyaDebabrata Mukhopadhyay

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