In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies.

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Ami PatelDavid B Weiner

Abstract

Antibody immunotherapy is revolutionizing modern medicine. The field has advanced dramatically over the past 40 years, driven in part by major advances in isolation and manufacturing technologies that have brought these important biologics to the forefront of modern medicine. However, the global uptake of monoclonal antibody (mAb) biologics is impeded by biophysical and biochemical liabilities, production limitations, the need for cold-chain storage and transport, as well as high costs of manufacturing and distribution. Some of these hurdles may be overcome through transient in vivo gene delivery platforms, such as non-viral synthetic plasmid DNA and messenger RNA vectors that are engineered to encode optimized mAb genes. These approaches turn the body into a biological factory for antibody production, eliminating many of the steps involved in bioprocesses and providing several other significant advantages, and differ from traditional gene therapy (permanent delivery) approaches. In this review, we focus on nucleic acid delivery of antibody employing synthetic plasmid DNA vector platforms, and RNA delivery, these being important approaches that are advancing simple, rapid, in vivo expression and having an impact in animal model...Continue Reading

References

Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·M MesnilH Yamasaki
Sep 1, 1996·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·S L Smith
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Jan 10, 2002·Human Gene Therapy·Jay N LozierRichard A Morgan
Jan 11, 2003·Cancer Gene Therapy·Tony ReidDavid Kirn
Jun 5, 2003·Nature Genetics·Hiroyuki NakaiMark A Kay
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara SpiesHermann Wagner
Mar 10, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Torunn Elisabeth TjelleBjarne Bogen
Mar 25, 2004·Genetic Vaccines and Therapy·Norma PerezMireia Pelegrin
Feb 25, 2005·Blood·Karin C StraathofCliona M Rooney
Jun 24, 2006·The Journal of Biological Chemistry·William F Dall'AcquaHerren Wu
Jul 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Siok-Keen TeyMalcolm K Brenner
Jul 28, 2007·Science·Anthony DonsanteMark S Sands
Dec 7, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bishnu P DeJulie L Boyer
Jun 19, 2008·Nucleic Acids Research·Rudy JulianoHyumin Kang
Jul 11, 2008·Expert Opinion on Biological Therapy·Michael Boyiadzis, Kenneth A Foon
Sep 18, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Katalin KarikóDrew Weissman
Nov 26, 2008·Nature Reviews. Genetics·Henrik KaessmannManyuan Long
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yik Andy YeungHenry B Lowman
Aug 4, 2009·Virus Research·Anurag SharmaSuresh K Mittal
Sep 19, 2009·Nature Reviews. Genetics·Richard Cordaux, Mark A Batzer
Jan 19, 2010·Nature Biotechnology·Jonathan ZalevskyJohn R Desjarlais
Mar 11, 2011·Nature Biotechnology·Andrew R M BradburyJohn McCafferty
May 3, 2011·Current Opinion in Immunology·Niranjan Y Sardesai, David B Weiner
Sep 22, 2011·Journal of Pharmaceutical Sciences·Timothy M LauerBernhardt L Trout
Nov 1, 2011·Nature·J Kenneth BaillieGeoffrey J Faulkner
Dec 6, 2011·Nature·Alejandro B BalazsDavid Baltimore
Apr 25, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuan ZhangLeaf Huang
Dec 14, 2012·BMJ : British Medical Journal·Allen F Shaughnessy
May 31, 2013·Science Translational Medicine·Maria P LimberisJames M Wilson
Aug 1, 2014·Geburtshilfe und Frauenheilkunde·C JackischB Ataseven
Sep 12, 2014·Clinical and Vaccine Immunology : CVI·Virginie S AdamMaria P Limberis
Jan 22, 2015·The Journal of Clinical Investigation·Randy J ChandlerCharles P Venditti

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Citations

Jun 25, 2020·Emerging Microbes & Infections·Chasity D AndrewsRachel A Liberatore
Nov 11, 2020·Pathogens·Jamal HussenAbdullah I A Al-Mubarak
Jun 24, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Thomas Kieber-Emmons
Aug 24, 2021·Applied Microbiology and Biotechnology·Hilal Ahmad ParrayRajesh Kumar
Oct 28, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andrea L J Marschall
Aug 14, 2021·Current Opinion in Allergy and Clinical Immunology·Alain Jacquet

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Methods Mentioned

BETA
transfection
lavage
biopsies
enzyme-linked immunosorbent assay
glycosylation

Clinical Trials Mentioned

NCT03831503
NCT03829384

Software Mentioned

Igea
Moderna

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