PMID: 2984582Jan 1, 1985

In vivo demonstration of alpha-2-adrenoceptor-mediated inhibition of the excitatory non-cholinergic neurotransmission in guinea pig airways

Naunyn-Schmiedeberg's Archives of Pharmacology
N Grundström, R G Andersson

Abstract

In anaesthetized guinea pigs, vagal nerve stimulation caused an atropine- and hexamethonium-resistant increase in the respiratory insufflation pressure. Clonidine (0.05 mg/kg i.v.) inhibited the increase in insufflation pressure caused by vagal stimulation. This effect of clonidine was antagonized by the alpha-2-antagonist yohimbine (0.5 mg/kg i.v.), but not by the alpha-1-antagonist prazosin (0.03 mg/kg i.v.). In conclusion, the increase in the respiratory insufflation pressure, caused by stimulation of noncholinergic nerves, seemed to be controlled by inhibitory alpha-2-adrenoceptors in guinea pig airways.

References

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Citations

May 28, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R FrancoJ B Furness
Aug 1, 1981·Acta Pharmacologica Et Toxicologica·N GrundströmJ E Wikberg
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergK Folkers
Dec 1, 1982·Acta Physiologica Scandinavica·J M Lundberg, A Saria
Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·C R MartlingJ M Lundberg
Mar 1, 1984·Acta Physiologica Scandinavica·J A Karlsson, C G Persson
Apr 22, 1983·European Journal of Pharmacology·C AdvenierB Mallard

Related Concepts

Nervousness
Vagal Stimulation
Cavia
Airway Resistance
Antagonist Muscle Action
Synaptic Transmission
Atropine
Trachea
Atropinum, atropine
Etiology

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