PMID: 2984582Jan 1, 1985

In vivo demonstration of alpha-2-adrenoceptor-mediated inhibition of the excitatory non-cholinergic neurotransmission in guinea pig airways

Naunyn-Schmiedeberg's Archives of Pharmacology
N Grundström, R G Andersson


In anaesthetized guinea pigs, vagal nerve stimulation caused an atropine- and hexamethonium-resistant increase in the respiratory insufflation pressure. Clonidine (0.05 mg/kg i.v.) inhibited the increase in insufflation pressure caused by vagal stimulation. This effect of clonidine was antagonized by the alpha-2-antagonist yohimbine (0.5 mg/kg i.v.), but not by the alpha-1-antagonist prazosin (0.03 mg/kg i.v.). In conclusion, the increase in the respiratory insufflation pressure, caused by stimulation of noncholinergic nerves, seemed to be controlled by inhibitory alpha-2-adrenoceptors in guinea pig airways.


Feb 24, 1987·European Journal of Pharmacology·B R LindgrenR G Andersson
Aug 16, 1991·European Journal of Pharmacology·M RechtmanA L Boura
Jan 1, 1990·Molecular Aspects of Medicine·P J Barnes
Jan 1, 1987·Pharmacology & Therapeutics·R G Andersson, N Grundström
Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
May 1, 1990·Trends in Pharmacological Sciences·P J BarnesD F Rogers
Nov 11, 1998·European Journal of Pharmacology·K MatsumotoN Hara
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology·M Rechtman
Jun 1, 1991·Journal of Autonomic Pharmacology·C A Maggi
Sep 1, 1993·British Journal of Pharmacology·M Rechtman, H Majewski
Dec 1, 1996·British Journal of Pharmacology·H NinomiyaS Hasegawa
Nov 1, 1985·Acta Physiologica Scandinavica·N Grundström, R G Andersson
Nov 1, 1990·The Journal of Pharmacy and Pharmacology·A MacDonaldP W Dettmar
Apr 1, 1996·The Journal of Pharmacy and Pharmacology·P NieriM C Breschi
Dec 1, 1987·The American Review of Respiratory Disease·P J Barnes
Sep 1, 1988·The American Review of Respiratory Disease
Mar 1, 1991·The American Review of Respiratory Disease·P J Barnes
Dec 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Nov 3, 2006·American Journal of Veterinary Research·Renaud Léguillette, Jean-Pierre Lavoie
Sep 29, 1999·Pulmonary Pharmacology & Therapeutics·J A Karlsson, R W Fuller
May 1, 1988·Equine Veterinary Journal·G C WatneyA M Nolan
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P J Barnes
Oct 1, 1988·British Journal of Pharmacology·M G BelvisiP J Barnes


May 28, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R FrancoJ B Furness
Aug 1, 1981·Acta Pharmacologica Et Toxicologica·N GrundströmJ E Wikberg
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M LundbergK Folkers
Dec 1, 1982·Acta Physiologica Scandinavica·J M Lundberg, A Saria
Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·C R MartlingJ M Lundberg
Mar 1, 1984·Acta Physiologica Scandinavica·J A Karlsson, C G Persson
Apr 22, 1983·European Journal of Pharmacology·C AdvenierB Mallard

Related Concepts

Vagal Stimulation
Airway Resistance
Antagonist Muscle Action
Synaptic Transmission
Atropinum, atropine

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