In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

European Radiology
Enrico TedeschiM Quarantelli

Abstract

To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA). In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis. The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p<0.001), maintaining the same significance even when including MS-related factors. Instead, the DN R2* values correlated only with age (p=0.003), and not with GBCA administrations (p=0.67). In a subgroup of 35 patients for whom the administered GBCA subtype was known, the effect of GBCA on DN R1 appeared mainly related to linear GBCA. In RR-MS patients, the number of previous GBCA administrations correlates with R1 relaxation rates of DN, while R2* values rema...Continue Reading

References

Apr 13, 2005·Neurology·Boby Varkey MaramattomEdward P Lindell
Oct 11, 2005·Magnetic Resonance Imaging·Robert J OggSue C Kaste
Apr 7, 2007·Journal of Neuropathology and Experimental Neurology·Jack van HorssenLars Bø
Apr 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·G R DaviesD H Miller
Jun 23, 2010·European Radiology·Frederik L GieselMarco Essig
Sep 17, 2010·Radiology·Christian LangkammerStefan Ropele
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean C L DeoniDeclan G M Murphy
Apr 16, 2011·AJNR. American Journal of Neuroradiology·M AbsintaM Filippi
May 27, 2011·Topics in Magnetic Resonance Imaging : TMRI·Sean C L Deoni
Mar 14, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Daniel T Ginat, Steven P Meyers
Sep 19, 2012·Journal of Magnetic Resonance Imaging : JMRI·Hai-Ling Margaret ChengGraham A Wright
Oct 24, 2012·Journal of Magnetic Resonance Imaging : JMRI·Dapeng HaoMichael Tweedle
May 3, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Stefan RopeleFranz Fazekas
May 24, 2014·AJNR. American Journal of Neuroradiology·E KanalH A Rowley
Sep 19, 2014·Lancet Neurology·Roberta J WardLuigi Zecca
Oct 31, 2014·Annals of Clinical and Translational Neurology·Guillaume BonnierCristina Granziera
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Aug 19, 2015·PloS One·Giuseppe PalmaMarcello Mancini
May 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yueer YanYi Tang

❮ Previous
Next ❯

Citations

Sep 16, 2016·Magnetic Resonance Imaging·Alexander Radbruch
Apr 1, 2017·La Radiologia medica·Enrico TedeschiArturo Brunetti
Jun 28, 2017·Lancet Neurology·Vikas GulaniUNKNOWN International Society for Magnetic Resonance in Medicine
Apr 1, 2017·The Journal of Vascular Access·Hana Malikova, Michal Holesta
Nov 7, 2017·World Journal of Radiology·Enricomaria MorminaMatilde Inglese
Sep 22, 2017·Magnetic Resonance Insights·Jan Endrikat, Nicoletta Anzalone
Mar 11, 2018·Clinical Neuroradiology·Richard PullicinoKumar Das
Apr 28, 2018·Andrologia·F Beyazal CelikerM Kösem
Dec 5, 2018·Journal of Magnetic Resonance Imaging : JMRI·Enedino Hernández-TorresAlexander Rauscher
Jan 13, 2018·Nature Reviews. Neurology·Carmen TurOlga Ciccarelli
Dec 18, 2018·Recent Patents on Biotechnology·Feng LinYi Wang
Jul 28, 2017·The British Journal of Radiology·Tomonori KandaShigeru Furui
Sep 27, 2018·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Andreu F CostaNicola Schieda
Feb 26, 2020·Investigative Radiology·Katerina Deike-HofmannAlexander Radbruch
Jan 11, 2020·Journal of Magnetic Resonance Imaging : JMRI·Elif Dilara TopcuogluYasar Bukte
Oct 21, 2017·AJNR. American Journal of Neuroradiology·S CocozzaG Palma
Dec 24, 2018·AJNR. American Journal of Neuroradiology·G PontilloA Brunetti
Jul 26, 2017·Clinical Neuroradiology·Andreas MüllerElke Hattingen
Jan 11, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jin Woo Choi, Won-Jin Moon
Apr 4, 2017·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Enrico TedeschiGiuseppe Palma
Apr 2, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Fatma Beyazal CelikerEngin Dursun
May 5, 2018·La Radiologia medica·Sergio SalernoPaolo Tomà
Nov 11, 2018·European Radiology·Carlo C QuattrocchiUNKNOWN GREC, European Gadolinium Retention Evaluation Consortium and the ESNR, European Society of Neuroradiology
Apr 24, 2021·AJNR. American Journal of Neuroradiology·G PontilloG Palma
Apr 24, 2021·AJNR. American Journal of Neuroradiology·K Ozturk, D Nascene
May 28, 2021·Brain Pathology·Samuel MalartreYves Allenbach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.