In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide

International Journal of Clinical Oncology
Mohammed AlbatanyRobert Bartha

Abstract

Glioblastoma is an aggressive brain cancer that is very difficult to treat. Clinically, it is important to be able to distinguish aggressive from non-aggressive brain tumors. Previous studies have shown that some drugs can induce a rapid change in intracellular pH that could help to identify aggressive cancer. The sodium proton exchanger (NHE1) plays a significant role in maintaining pH balance in the tumor microenvironment. Cariporide is a sodium proton exchange inhibitor that is well tolerated by humans in cardiac applications. We hypothesized that cariporide could selectively acidify brain tumors. The purpose of this study was to determine whether amine/amide concentration-independent detection (AACID) chemical exchange saturation transfer (CEST) MRI measurement of tumor pHi could detect acidification after cariporide injection. Using a 9.4T MRI scanner, CEST spectra were acquired in six mice approximately 14 days after implanting 105 U87 human glioblastoma multiforme cells in the brain, before and after administration of cariporide (dose: 6 mg/kg) by intraperitoneal injection. Three additional mice were studied as controls and received only vehicle injection (DMSO + PBS). Repeated measures t test was used to examine changes...Continue Reading

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Citations

Aug 9, 2019·Journal of Neuro-oncology·Mohammed AlbatanyRobert Bartha
Mar 7, 2020·Frontiers in Oncology·Lorena ConsolinoDario Livio Longo
Jan 27, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feriel RomdhaneDario Livio Longo
Dec 9, 2020·International Journal of Molecular Sciences·Tomas Koltai
Jul 3, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jelena DinićIvanka Tsakovska

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