In vivo detection of gastric cancer in rats by electron paramagnetic resonance imaging

Cancer Research
Tomiko MikuniJay L Zweier

Abstract

Electron paramagnetic resonance imaging (EPRI) enables noninvasive spatial mapping of free radical metabolism and has recently been shown to provide in vivo physiologic information regarding alterations in the redox state of tumors and neoplastic tissues. With the use of nitroxide spin probes, it has been shown that certain tumors possess a highly reduced state. To determine whether EPRI can be used for early detection and visualization of gastric carcinoma based on its altered redox metabolism, studies were performed in a rat gastric cancer model induced by 1-methyl-3-nitro-1-nitrosoguanidine. Using a specialized 750 MHz resonator and EPRI instrument, a technique was developed for imaging nitroxide radicals in the whole stomach. In vivo three-dimensional EPRI of the stomach of rats with continuous intravenous administration of nitroxide 3-carboxamido-2,2,5,5-tetramethylpyrrolidine-N-oxyl (3-carbamoyl-proxyl) [3-CP] was performed. Whereas electron paramagnetic resonance images from untreated controls provide a uniform visualization of the stomach mucosa and wall, in the treated rats with gastric cancer, holes were present in the image at the locations of tumors. With localized spectroscopy, it was confirmed that the tumor regio...Continue Reading

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Mar 2, 2012·Free Radical Research·Kazuhiro Ichikawa, Keiji Yasukawa
Nov 30, 2007·Free Radical Biology & Medicine·Samarjit DasDipak K Das
Apr 17, 2007·Journal of Magnetic Resonance·Ken-ichiro MatsumotoNobuo Ikota
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Jun 22, 2021·Antioxidants & Redox Signaling·Ken-Ichiro MatsumotoIchio Aoki

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