In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models

Analytical and Bioanalytical Chemistry
Janna K RegisterTuan Vo-Dinh

Abstract

Surface-enhanced Raman scattering (SERS)-active plasmonic nanomaterials have become a promising agent for molecular imaging and multiplex detection. Among the wide variety of plasmonics-active nanoparticles, gold nanostars offer unique plasmon properties that efficiently induce strong SERS signals. Furthermore, nanostars, with their small core size and multiple long thin branches, exhibit high absorption cross sections that are tunable in the near-infrared region of the tissue optical window, rendering them efficient for in vivo spectroscopic detection. This study investigated the use of SERS-encoded gold nanostars for in vivo detection. Ex vivo measurements were performed using human skin grafts to investigate the detection of SERS-encoded nanostars through tissue. We also integrated gold nanostars into a biocompatible scaffold to aid in performing in vivo spectroscopic analyses. In this study, for the first time, we demonstrate in vivo SERS detection of gold nanostars using small animal (rat) as well as large animal (pig) models. The results of this study establish the usefulness and potential of SERS-encoded gold nanostars for future use in long-term in vivo analyte sensing.

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Citations

Jan 25, 2017·ACS Applied Materials & Interfaces·Sivaprasad Chinnakkannu VijayakumarBo Tan
Mar 9, 2017·Chemical Reviews·Jian-Feng LiZhong-Qun Tian
May 26, 2017·Physical Chemistry Chemical Physics : PCCP·Yevgeniya KalachyovaOleksiy Lyutakov
Mar 10, 2020·Drug Metabolism Reviews·Seyyed Mojtaba MousaviAhmad Gholami
Oct 3, 2020·The Analyst·Gregory Q Wallace, Jean-François Masson
Mar 17, 2017·Annual Review of Analytical Chemistry·Lauren E JamiesonDuncan Graham
Apr 10, 2018·Current Opinion in Chemical Biology·Lucas A LaneShuming Nie

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