In vivo detection of thalamic gliosis: a pathoradiologic demonstration in familial fatal insomnia

Archives of Neurology
Stéphane HaïkJean-Philippe Brandel

Abstract

Increasing evidence supports the usefulness of brain magnetic resonance imaging (MRI) for the diagnosis of human prion diseases. From the neuroradiological point of view, fatal familial insomnia is probably the most challenging to diagnose because brain lesions are mostly confined to the thalamus. To determine whether multisequence MRI of the brain can show thalamic alterations and establish pathoradiologic correlations in a patient with familial fatal insomnia. Radioclinical prospective study. We describe a patient with fatal familial insomnia and normal MRI images. Because the MRI study was performed only 4 days before the patient's death, we were able to compare radiological data with the lesions observed at the neuropathologic level. A 55-year-old man with familial fatal insomnia. Magnetic resonance spectroscopy combined with the measurement of apparent diffusion coefficient of water in different brain areas. The neuroradiological study showed, in the thalamus but not in the other brain regions studied, an increase of apparent diffusion coefficient of water and a metabolic pattern indicating gliosis. These alterations closely correlated with neuropathologic data showing an almost pure gliosis that was restricted to the thal...Continue Reading

Citations

May 1, 2010·AJNR. American Journal of Neuroradiology·Damien GalanaudJ-P Brandel
Mar 30, 2013·AJNR. American Journal of Neuroradiology·E De VitaH Hyare
Mar 18, 2011·Journal of Neuropathology and Experimental Neurology·Jean-Jacques HauwDanielle Seilhean
Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Oriol Grau-RiveraRaquel Sánchez-Valle
Jan 12, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kelly K Koeller, Robert Y Shih
Aug 6, 2017·Cold Spring Harbor Perspectives in Biology·Mee-Ohk KimMichael D Geschwind
Jun 27, 2018·Chinese Medical Journal·Li-Yong WuYu-Ping Wang
Apr 14, 2012·Journal of Magnetic Resonance Imaging : JMRI·Laurent Letourneau-GuillonWalter Kucharczyk
Apr 24, 2017·Neurochemical Research·Annamaria VezzaniTeresa Ravizza

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