In vivo differences in inputs and spiking between neurons in lobules VI/VII of neocerebellum and lobule X of archaeocerebellum

The Cerebellum
Laurens Witter, Chris I De Zeeuw

Abstract

The cerebellum plays an important role in the coordination and refinement of movements and cognitive processes. Recently, it has been shown that the main output neuron of the cerebellar cortex, i.e., the Purkinje cell, can show a different firing behavior dependent on its intrinsic electrophysiological properties. Yet, to what extent a different nature of mossy fiber inputs can influence the firing behavior of cerebellar cortical neurons remains to be elucidated. Here, we compared the firing rate and regularity of mossy fibers and neurons in two different regions of cerebellar cortex. One region intimately connected with the cerebral cortex, i.e., lobules VI/VII of the neocerebellum, and another one strongly connected with the vestibular apparatus, i.e., lobule X of the archaeocerebellum. Given their connections, we hypothesized that activity in neurons in lobules VI/VII and lobule X may be expected to be more phasic and tonic, respectively. Using whole-cell and cell-attached recordings in vivo in anesthetized mice, we show that the mossy fiber inputs to these functionally distinct areas of the cerebellum differ in that the irregularity and bursty character of their firing is significantly greater in lobules VI/VII than in lobu...Continue Reading

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Citations

Oct 10, 2015·The Cerebellum·Chris I De ZeeuwMarco Martina
Apr 18, 2015·Current Opinion in Neurobiology·Laurens Witter, Chris I De Zeeuw
Nov 17, 2016·PloS One·Cathrin B CantoChris I De Zeeuw
May 18, 2017·The Journal of Physiology·Yeechan Wu, Indira M Raman
Aug 30, 2018·The Journal of Comparative Neurology·Rong-Jun NiJiang-Ning Zhou
Apr 28, 2017·Journal of Neurophysiology·Reinoud Maex, Boris Gutkin
Nov 19, 2020·Nature Reviews. Neuroscience·Chris I De Zeeuw

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