In vivo diffusion MRS investigation of non-water molecules in biological tissues

NMR in Biomedicine
Peng Cao, Ed X Wu

Abstract

Diffusion MRS of non-water molecules offers great potential in directly revealing various tissue microstructures and physiology at both cellular and subcellular levels. In brain, 1 H diffusion MRS has been demonstrated as a new tool for probing normal tissue microstructures and their pathological changes. In skeletal muscle, 1 H diffusion MRS could characterize slow and restricted intramyocellular lipid diffusion, providing a sensitive marker for metabolic alterations, while 31 P diffusion MRS can measure ATP and PCr diffusion, which may reflect the capacity of cellular energy transport, complementing the information from frequently used 31 P MRS in muscle. In intervertebral disk, 1 H diffusion MRS can directly monitor extracellular matrix integrity by quantifying the mobility of macromolecules such as proteoglycans and collagens. In tumor tissue, 13 C diffusion MRS could probe intracellular glycolytic metabolism, while 1 H diffusion MRS may separate the spectrally overlapped lactate and lipid resonances. In this review, recent diffusion MRS studies of these biologically relevant non-water molecules under normal and diseased conditions will be presented. Technical considerations for diffusion MRS experiments will be discussed. ...Continue Reading

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P C Van ZijlJ S Cohen
Feb 19, 1990·Biochimica Et Biophysica Acta·K YoshizakiG K Radda
Mar 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C T MoonenD DesPres
Jan 1, 1987·Annals of the New York Academy of Sciences·P A Bottomley
Sep 21, 1995·Journal of Theoretical Biology·P S AgutterD N Wheatley
Oct 1, 1995·Stroke; a Journal of Cerebral Circulation·M WickJ Frahm
Jan 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y BitoE Yamamoto
Sep 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K L BeharO A Petroff
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P van GelderenC T Moonen
Sep 1, 1993·Radiology·S PosseD Le Bihan
Feb 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F SchickO Lutz
Nov 1, 1995·NMR in Biomedicine·D Le Bihan
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A van der ToornK Nicolay
Apr 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C BoeschR Kreis
Dec 24, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A L AlexanderD L Parker
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R M DijkhuizenK Nicolay
Apr 9, 1999·NMR in Biomedicine·S T KinseyT S Moerland
Mar 24, 2000·Journal of Magnetic Resonance·S CavassilaD Graveron-Demilly
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O AbeY Sasaki
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J PfeufferR Gruetter
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C LiessK Clarke
Dec 1, 2000·Journal of Magnetic Resonance·M SchachterJ C Gore
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W DreherD Leibfritz
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H LahrechM Décorps
Apr 26, 2001·NMR in Biomedicine·K NicolayM J Kruiskamp
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A de GraafK Nicolay
Jun 19, 2001·NMR in Biomedicine·S CavassilaD Graveron-Demilly
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L HofmannR Kreis
Nov 17, 2001·Magnetic Resonance Imaging·S Skare, J L Andersson
Feb 13, 2002·NMR in Biomedicine·Masafumi HaradaTsuyoshi Matsuda
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T G ReeseV J Wedeen
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark D DoesJohn C Gore
Feb 24, 1956·Science·O WARBURG
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christopher D KroenkeDmitriy A Yablonskiy
Jan 22, 2005·NMR in Biomedicine·H RatineyD Graveron-Demilly
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jacob EllegoodChristian Beaulieu
Aug 23, 2005·Journal of Magnetic Resonance·Josef PfeufferMichael Garwood

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Citations

Nov 1, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karl LandheerSimon J Graham
Feb 12, 2020·NMR in Biomedicine·Chris Hanstock, Christian Beaulieu
Jul 6, 2019·Journal of Magnetic Resonance Imaging : JMRI·Karl LandheerChristoph Juchem
Oct 30, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin FotsoStefan Posse
Nov 16, 2016·Journal of Lipid Research·Sanjay Kumar VermaS Sendhil Velan
Aug 11, 2017·NMR in Biomedicine·Masoumeh DehghaniRolf Gruetter
Oct 19, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dinesh K DeelchandMałgorzata Marjańska
Apr 25, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·André DöringRoland Kreis
Aug 9, 2018·Brain Structure & Function·Carson IngoItamar Ronen
Nov 5, 2020·Journal of Neuroscience Methods·Rafael N HenriquesAndrada Ianuş
Jul 22, 2020·Journal of Neuroscience Methods·Ileana O JelescuKurt G Schilling
Jul 20, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Florence FranconiPatrick Saulnier

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