In vivo Diffusion Tensor Imaging, Diffusion Kurtosis Imaging, and Tractography of a Sciatic Nerve Injury Model in Rat at 9.4T

Scientific Reports
Gustav AnderssonLev N Novikov

Abstract

Peripheral nerve injuries result in severe loss of sensory and motor functions in the afflicted limb. There is a lack of standardised models to non-invasively study degeneration, regeneration, and normalisation of neuronal microstructure in peripheral nerves. This study aimed to develop a non-invasive evaluation of peripheral nerve injuries, using diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), and tractography on a rat model of sciatic nerve injury. 10 female Sprague Dawley rats were exposed to sciatic nerve neurotmesis and studied using a 9.4 T magnet, by performing DTI and DKI of the sciatic nerve before and 4 weeks after injury. The distal nerve stump showed a decrease in fractional anisotropy (FA), mean kurtosis (MK), axonal water fraction (AWF), and radial and axonal kurtosis (RK, AK) after injury. The proximal stump showed a significant decrease in axial diffusivity (AD) and increase of MK and AK as compared with the uninjured nerve. Both mean diffusivity (MD) and radial diffusivity (RD) increased in the distal stump after injury. Tractography visualised the sciatic nerve and the site of injury, as well as local variations of the diffusion parameters following injury. In summary, the described method de...Continue Reading

References

Nov 1, 1991·Journal of Computer Assisted Tomography·P DouekD Le Bihan
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J StaniszR M Henkelman
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Evren Ozarslan, Thomas H Mareci
May 4, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chunlei LiuMichael E Moseley
Jun 3, 2004·Magnetic Resonance Imaging·Mikael SkorpilAnders Nordell
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Jan 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shu-Wei SunSheng-Kwei Song
Jan 18, 2006·Computer Methods and Programs in Biomedicine·Hangyi JiangSusumu Mori
Mar 21, 2007·Magnetic Resonance Imaging·Mikael SkorpilAnders Nordell
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Sep 18, 2008·Radiology·Taro TakaharaPeter R Luijten
Feb 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Dan SteinYaniv Assaf
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew D BuddeSheng-Kwei Song
Apr 14, 2009·Topics in Magnetic Resonance Imaging : TMRI·Tonya WhiteKelvin O Lim
Nov 3, 2009·Experimental Neurology·Helmar C LehmannKazim A Sheikh
May 11, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Heidi M FeldmanShayna Gaman-Bean
Sep 30, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jelle VeraartJan Sijbers
Feb 3, 2011·Journal of Magnetic Resonance Imaging : JMRI·Shinsuke MorisakiToshikazu Kubo
Jun 28, 2011·NeuroImage·Els FieremansJoseph A Helpern
Aug 31, 2012·Stroke; a Journal of Cerebral Circulation·Edward S HuiJoseph A Helpern
Mar 29, 2013·Radiological Physics and Technology·Issei FukunagaAtsushi Senoo
Jul 31, 2013·Hand Clinics·Ron M G MenorcaJohn C Elfar
Oct 23, 2013·Diagnostic and Interventional Imaging·M OhanaJ-L Dietemann
Dec 19, 2013·PloS One·Fang-Cheng YehWen-Yih Isaac Tseng
Dec 29, 2013·AJR. American Journal of Roentgenology·Andrew J StevenElias R Melhem
Sep 16, 2014·NeuroImage·Tim B DyrbyHartwig R Siebner
Jan 8, 2015·Stroke; a Journal of Cerebral Circulation·Rachel A WeberDeAnna L Adkins
Aug 16, 2015·NMR in Biomedicine·G Russell GlennJens H Jensen
Sep 2, 2015·Neurosurgical Focus·Richard B BoyerWesley P Thayer
May 6, 2017·AJNR. American Journal of Neuroradiology·M V SpampinatoW Feng
Mar 15, 2018·Frontiers in Neurology·Pawel J WinklewskiArkadiusz Szarmach

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Citations

Oct 16, 2019·Nanomedicine·Igor D LuzhanskyMikhail Y Berezin
Dec 25, 2019·Scientific Reports·Isaac V Manzanera EsteveRichard D Dortch
Aug 3, 2019·AJNR. American Journal of Neuroradiology·S ChungY W Lui
Jan 12, 2021·Rheumatology International·Josefina GutiérrezCarlos Pineda
Dec 8, 2020·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Ryckie G WadeGrainne Bourke
Jul 24, 2021·Scientific Reports·Timothy T GriffithsRyckie G Wade

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Methods Mentioned

BETA
imaging techniques
imaging technique

Software Mentioned

Grappa
ImageJ
DSI
ParaVison®
studio
SPSS Statistics

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