PMID: 7545945Sep 1, 1994Paper

In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop

Journal of Virology
Y DonaldsonP Simmonds

Abstract

The distribution, cell tropism, and cytopathology in vivo of human immunodeficiency virus (HIV) was investigated in postmortem tissue samples from a series of HIV-infected individuals who died either of complications associated with AIDS or for unrelated reasons while they were asymptomatic. Proviral sequences were detected at a high copy number in lymphoid tissue of both presymptomatic patients and patients with AIDS, whereas significant infection of nonlymphoid tissue such as that from brains, spinal cords, and lungs were confined to those with AIDS. V3 loop sequences from both groups showed highly restricted sequence variability and a low overall positive charge of the encoded amino acid sequence compared with those of standard laboratory isolates of HIV type 1 (HIV-1). The low charge and the restriction in sequence variability were comparable to those observed with isolates showing a non-syncytium-inducing (NSI) and macrophage-tropic phenotype in vitro. All patients were either exclusively infected (six of seven cases) or predominantly infected (one case) with variants with a predicted NSI/macrophage-tropic phenotype, irrespective of the degree of disease progression. p24 antigen was detected by immunocytochemical staining ...Continue Reading

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Citations

Dec 1, 2005·Brain : a Journal of Neurology·M McCrossanP Simmonds
Aug 21, 2010·Immunologic Research·K Grovit-Ferbas, M E Harris-White
Jan 26, 1995·The New England Journal of Medicine·G PantaleoL K Schrager
Apr 10, 1996·AIDS Research and Human Retroviruses·M Di StefanoF Chiodi
Jul 23, 2004·Evolution; International Journal of Organic Evolution·Rafael SanjuánSantiago F Elena
Jul 31, 1999·European Journal of Immunology·P KelleherS C Knight
Jan 20, 1996·AIDS Research and Human Retroviruses·D BhattacharyyaL Callahan
Aug 15, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·R SutthentC Wasi
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeanne E BellPeter Simmonds
Dec 22, 2010·AIDS·Rebecca R GrayMaureen M Goodenow
Apr 10, 1996·AIDS Research and Human Retroviruses·R T ReddyC A Wiley
Jun 19, 2001·Virus Research·K M McGrathR Swanstrom
Oct 4, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Saleta SierraRolf Kaiser
Jan 28, 2012·BMC Veterinary Research·Hugo RamírezDamián de Andrés

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