PMID: 11340584May 8, 2001Paper

In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy

International Journal of Cancer. Journal International Du Cancer
P K SelboKristian Berg

Abstract

Photochemical internalization (PCI) is a unique procedure for site-specific delivery of several types of membrane-impermeable molecules to the cytosol of target cells. The technology is based on photochemical-induced release of endocytosed macromolecules from endosomes and lysosomes into the cytosol. The purpose of this study was to evaluate the therapeutic potential of PCI of the type I ribosomal-inactivating protein gelonin in an animal model. The photosensitizer aluminum phthalocyanine disulfonate (AlPcS(2a)) was injected intraperitoneally (10 mg/kg) into athymic female BALB/c (nu/nu) nude mice (8-9 mice per group) with subcutaneously growing human adenocarcinoma (WiDr) tumors 48 hr before exposure to 135 J/cm(2) of red light focused on the tumor. Six hours before light exposure a single dose of 50 microg gelonin was administrated intratumorally. Tumor growth was measured at least twice a week. After immunomagnetic separation of in vivo growing tumor cells the subcellular localization of the photosensitizer was evaluated by fluorescence microscopy. The photosensitizer localized in endocytic vesicles in in vivo growing WiDr cells. Furthermore, it was found that in vitro gelonin treatment of WiDr cells isolated from photosensi...Continue Reading

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Citations

Jul 14, 2007·European Biophysics Journal : EBJ·Halina MojzisovaDaniel Brault
Jan 7, 2004·Advanced Drug Delivery Reviews·Anders HøgsetKristian Berg
Apr 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Monica BostadPål K Selbo
Nov 26, 2002·Cancer Letters·Tetsuya KodamaMichael R Hamblin
Jun 13, 2006·Oligonucleotides·S Bøe, E Hovig
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Jul 22, 2010·Oligonucleotides·Sigurd Leinaes BøeEivind Hovig
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Dec 24, 2011·Head & Neck Oncology·Waseem JerjesColin Hopper
Oct 10, 2006·The AAPS Journal·Yingjuan LuEmanuela Sega
Jan 20, 2006·Photochemistry and Photobiology·Lina PrasmickaiteKristian Berg
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Dec 11, 2014·Therapeutic Delivery·Janely Pae, Margus Pooga
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Sep 1, 2004·Expert Opinion on Biological Therapy·Lina PrasmickaiteKristian Berg
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Feb 22, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pål Kristian SelboKristian Berg
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Jul 28, 2007·International Journal of Pharmaceutics·Stéphanie BonneauDaniel Brault
Jun 1, 2007·Photodiagnosis and Photodynamic Therapy·Asta Juzeniene, Johan Moan
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Sep 23, 2006·International Journal of Cancer. Journal International Du Cancer·Pei-Jen LouStephen G Bown
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Nov 8, 2011·Lasers in Surgery and Medicine·Anette WeyergangKristian Berg
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Feb 10, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anette WeyergangKristian Berg
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Mar 12, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Monica BostadPål Kristian Selbo
Mar 26, 2015·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Pål Kristian SelboKristian Berg

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