PMID: 6403788Mar 21, 1983Paper

In vivo dopamine receptor binding studies with a non-radioactively labeled agonist, dipropyl-5,6-ADTN

Life Sciences
M G FeenstraA S Horn

Abstract

Evidence is presented that a low dose of peripherally administered N,N-dipropylamino-5,6-dihydroxytetralin (DiPr-5,6-ADTN) specifically labels dopamine (DA) receptors in rat brain. Concentrations of this potent DA receptor agonist were determined by a highly selective method using reversed phase liquid chromatography and amperometric detection. The binding characteristics satisfy all criteria regarding saturability, stereospecificity, regional distribution and relation with pharmacological effects that are associated with DA receptor interactions. A rough estimation of the density of binding sites in the striatum resulted in values of 60-70 pmol/g. Lesioning the nigrostriatal pathway does not significantly alter the amount of ligand bound, nor do pretreatments with serotonergic, alpha-adrenergic or beta-adrenergic antagonists. DiPr-5,6-ADTN has thus been shown to be a useful ligand for labeling central DA receptors and a powerful tool in the study of DA-ergic mechanisms.

References

Aug 24, 1979·Brain Research·S I RapoportK D Pettigrew
Oct 12, 1978·Nature·M J WilliamsonP Skolnick
May 15, 1975·Life Sciences·C B Pert, S H Snyder
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P SokoloffJ C Schwartz

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Citations

Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M G FeenstraA S Horn
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·K SvenssonA Carlsson
Jul 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·S HjorthB Andersson
Jun 17, 1983·European Journal of Pharmacology·M G FeenstraA S Horn
Mar 1, 1993·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S ZijlstraW Vaalburg
Jul 1, 1983·The Journal of Pharmacy and Pharmacology·M G FeenstraA S Horn
May 1, 1985·The Journal of Pharmacy and Pharmacology·H RollemaA S Horn

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