In vivo dose measurement using TLDs and MOSFET dosimeters for cardiac radiosurgery.

Journal of Applied Clinical Medical Physics
Edward A GardnerPatrick Maguire

Abstract

In vivo measurements were made of the dose delivered to animal models in an effort to develop a method for treating cardiac arrhythmia using radiation. This treatment would replace RF energy (currently used to create cardiac scar) with ionizing radiation. In the current study, the pulmonary vein ostia of animal models were irradiated with 6 MV X-rays in order to produce a scar that would block aberrant signals characteristic of atrial fibrillation. The CyberKnife radiosurgery system was used to deliver planned treatments of 20-35 Gy in a single fraction to four animals. The Synchrony system was used to track respiratory motion of the heart, while the contractile motion of the heart was untracked. The dose was measured on the epicardial surface near the right pulmonary vein and on the esophagus using surgically implanted TLD dosimeters, or in the coronary sinus using a MOSFET dosimeter placed using a catheter. The doses measured on the epicardium with TLDs averaged 5% less than predicted for those locations, while doses measured in the coronary sinus with the MOSFET sensor nearest the target averaged 6% less than the predicted dose. The measurements on the esophagus averaged 25% less than predicted. These results provide an indi...Continue Reading

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Citations

Mar 1, 2017·International Journal of Radiation Oncology, Biology, Physics·Mark ChanOliver Blanck
Apr 20, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Oliver BlanckHendrik Bonnemeier
Nov 8, 2020·International Journal of Radiation Oncology, Biology, Physics·Suzanne Lydiard PGDipPaul Keall
Feb 17, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A Munshi
May 6, 2021·Trends in Cardiovascular Medicine·John WhitakerPaul C Zei

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Methods Mentioned

BETA
X‐ray
chips

Software Mentioned

MultiPlan
CARTO
CyberHeart

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