In vivo effects of aspirin and cyclosporine on regulatory T cells and T-cell cytokine production in healthy dogs

Veterinary Immunology and Immunopathology
T M ArcherA J Mackin

Abstract

Cyclosporine and aspirin are routinely used in combination to treat immune-mediated hemolytic anemia (IMHA) in dogs. Cyclosporine is a potent immunosuppressive agent that targets T cell production of the cytokines IL-2 and IFN-γ. Low-dose aspirin is often used to inhibit platelet function in dogs with IMHA, since these animals are prone to life-threatening thromboembolic disease. In rodents and humans, aspirin and cyclosporine have both been shown to variably affect T cell cytokine production, and also numbers of circulating regulatory T cells (Tregs). In dogs, it has not yet been determined if concurrent aspirin alters the effects of cyclosporine on T-cell cytokine expression, or if either drug influences Treg numbers. In a crossover study, seven healthy young adult dogs were given either oral high-dose cyclosporine (10 mg/kg Q12 h), oral low-dose aspirin (1 mg/kg Q24 h), oral high-dose aspirin (10 mg/kg Q12 h), or combined low-dose aspirin with cyclosporine, each for 8 days, with a washout of at least 2 weeks after each treatment. Activated T cell cytokine expression (IL-2 & IFN-γ) and percent CD4 + CD25 + FOXP3+ Tregs were evaluated using flow cytometry, both prior to and on the last day of treatment. The difference between ...Continue Reading

References

Jul 1, 1977·Arthritis and Rheumatism·M W DuncanJ T Sharp
Dec 11, 2003·The Veterinary Clinics of North America. Small Animal Practice·Sheila McCullough
Mar 26, 2004·Transplantation Proceedings·M H KapturczakB Kaplan
Mar 15, 2005·Clinical and Experimental Immunology·K SchroecksnadelD Fuchs
Jun 7, 2005·Journal of the American Veterinary Medical Association·Tristan K WeinkleHollis N Erb
May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Haiying Liu, Bernard P Leung
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Xavier Valencia, Peter E Lipsky
Nov 26, 2010·Autoimmunity·Elaine V Lourenço, Antonio La Cava
Jan 14, 2011·Veterinary Immunology and Immunopathology·C L FellmanA J Mackin
Nov 19, 2011·Journal of Veterinary Internal Medicine·T M ArcherA J Mackin
Dec 17, 2011·International Immunopharmacology·Muzammal HussainMuti Ur Rehman
Mar 19, 2013·International Immunopharmacology·Xiao-Jun WangPiotr Witkowski
Dec 18, 2013·Journal of Veterinary Internal Medicine·T M ArcherA J Mackin
Dec 18, 2015·Journal of Veterinary Pharmacology and Therapeutics·C L FellmanA J Mackin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.