PMID: 2499552Jun 15, 1989Paper

In vivo effects of combination treatment with recombinant interferon-gamma and -alpha in metastatic melanoma

International Journal of Cancer. Journal International Du Cancer
S OsantoF J Cleton

Abstract

The toxicity and therapeutic efficacy of the combination of recombinant interferon gamma (rIFN-gamma) and alpha (rIFN-alpha) was investigated in 15 patients with metastatic melanoma. Patients were treated with an escalating dose of rIFN-gamma and a fixed dose of rIFN-alpha administered s.c. 3 times a week. The maximum dose was well tolerated. The median survival time of the patients was 7 months; no clinical remissions were observed. In the majority of cases, expression of HLA class-I and -II antigens on the patients' peripheral blood lymphocytes and monocytes increased markedly during treatment. An increase in HLA-DR expression of peripheral blood T lymphocytes was correlated with a longer survival time. This suggests that activation of T lymphocytes may have a favourable influence on the course of metastatic disease. The in vitro anti-proliferative activity of IFNs on melanoma cell lines isolated from melanoma metastases during treatment of 3 patients was determined. In contrast to the lack of in vivo anti-tumour effect in patients, both rIFN-gamma and rIFN-alpha inhibited DNA synthesis of these melanoma cell lines in vitro, combined IFNs acting synergistically. Anti-proliferative activity observed in vitro occurred at IFN co...Continue Reading

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Citations

Sep 1, 1993·Cancer Immunology, Immunotherapy : CII·K M Heaton, E A Grimm
Jun 14, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jonathan LarkinJohn I Glass
Sep 1, 1995·The British Journal of Ophthalmology·I de Waard-SiebingaM J Jager
Aug 12, 1993·Annals of the New York Academy of Sciences·M K Wallack, M Sivanandham
Jan 1, 1992·Clinics in Dermatology·P I Schrier
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S OsantoJ T van Dissel
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M J DobrzanskiR W Dutton
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles F EisenbeisWilliam E Carson
Nov 2, 2018·The Journal of Experimental Medicine·Ryan S LaneAmanda W Lund
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory B LesinskiWilliam E Carson
Dec 1, 1990·The Journal of Investigative Dermatology·J M Kirkwood, M S Ernstoff

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