In vivo effects of di-n-butyltin dichloride on some enzymes and lipids of rat liver plasma membrane

Toxicology Letters
S C Srivastava

Abstract

The in vivo effects of di-n-butyltin dichloride (DBT) on the enzyme activity and lipid constituents of liver plasma membrane were studied in male Albino rats. The rats were intraperitoneally administered with 0.1 ml (10% v/v) ethanol either alone or containing DBT (10 or 30 mg/kg/d) for 7 consecutive days. A significant inhibition of plasma membrane marker enzymes such as 5'-nucleotidase, gamma-glutamyltranspeptidase, alkaline phosphatase, Mg2(+)-ATPase, Na+/K(+)-ATPase and Ca2(+)-ATPase occurred in DBT-treated rats when compared with respective controls. Other important bioconstituents such as sialic acid and total phospholipid/cholesterol ratio were also significantly decreased in DBT-treated rats when compared with corresponding controls. These results suggest that interaction of DBT with liver plasma membrane constituents might cause derangement of its structural and functional organization, thus leading to hepatotoxicity.

References

Jul 15, 1975·European Journal of Biochemistry·L R SchwarzH Greim
Aug 1, 1988·Infusionstherapie : offizielles Organ der Deutschen Arbeitsgemeinschaft für Künstliche Ernährung (DAKE) ; offizielles Organ der Österreichischen Arbeitsgemeinschaft für Klinische Ernähru (AKE) ; offizielles Organ der Deutschen Gesellschaft für Transfusion·J M Kinney
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B F Scharschmidt, J E Stephens
Jul 1, 1961·Archives of Biochemistry and Biophysics·W OSTROWSKI, A TSUGITA

Citations

Mar 15, 2005·Biochemical Pharmacology·Ruili HuangDavid G Covell
Aug 16, 2012·The Science of the Total Environment·Anne Lill GadeKetil Hylland
Jan 1, 1996·Critical Reviews in Toxicology·K Fent

Related Concepts

Dibutyldichlorotin
DNA-dependent ATPase
Alkaline Phosphatase
Metazoa
Plasma Membrane
Gamma-glutamyl transferase
Injections, Intraperitoneal
Liver
Organotin Compounds
5'-NUCLEOTIDASE

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