In vivo effects of hepatocyte growth factor/scatter factor on mouse mammary gland development

Experimental Cell Research
J YantT Kamalati

Abstract

We have recently demonstrated the regulated expression of HGF/SF and its receptor (c-met) during mouse mammary gland development together with the mitogenic, motogenic and morphogenic effects of exogenous HGF/SF on primary mammary epithelial cells in culture. This study was undertaken to analyze the influence of HGF/SF on reconstituted mouse mammary gland development in vivo. Here we report that overexpression of HGF/SF induces a range of alterations in the architecture of virgin mouse mammary gland. These include an enhancement of ductal end bud (mammary gland morphoregulatory control point) size and numbers and hyperplastic branching morphogenesis. These data are the first demonstration of the effects of HGF/SF on mammary epithelium in vivo.

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Citations

Nov 23, 2006·Journal of Mammary Gland Biology and Neoplasia·Pengfei LuZena Werb
Jul 24, 2010·Tissue Engineering. Part a·Amira L PavlovichCeleste M Nelson
Mar 20, 2009·Molecular Biology of the Cell·Bénédicte FoveauDavid Tulasne
Dec 19, 2003·Breast Cancer Research : BCR·Jimmie E FataMina J Bissell
Mar 23, 2011·Annals of Medicine·Sara McNally, Finian Martin
Apr 5, 2011·Experimental Cell Research·Amira L PavlovichCeleste M Nelson
Jul 14, 2010·Journal of Molecular Signaling·Kelly L MuellerJulie L Boerner
Apr 19, 2015·Breast Cancer Research : BCR·Colan M Ho-YenStephanie Kermorgant
Oct 27, 2009·Mechanisms of Development·Sheau-Ling LeeRobert B Dickson
Nov 8, 2006·Journal of Mammary Gland Biology and Neoplasia·Jillian HowlinFinian Martin
Jan 10, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonathan LefebvreDavid Tulasne
Jul 3, 2019·International Journal of Cancer. Journal International Du Cancer·Xiang ShuWei Zheng
Jun 20, 2019·International Journal of Molecular Sciences·Nawaphat JangphattananontKunio Matsumoto
Dec 14, 2018·International Journal of Molecular Sciences·Chiara ModicaElisa Vigna

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