In vivo effects of insulin-like growth factor-I on the development of sensory pathways: analysis of the primary somatic sensory cortex (S1) of transgenic mice

Endocrinology
G Gutierrez-OspinaA J D'Ercole

Abstract

In the rodent brain, insulin-like growth factor I (IGF-I) messenger RNA is transiently expressed in sensory projection neurons during periods of synaptogenesis and neuronal growth. Transgenic (Tg) mice with brain IGF-I overexpression and ectopic brain expression of IGF-binding protein-1 (IGFBP-1), an inhibitor of IGF-I actions, show changes in brain size and myelination. We used these mouse models to evaluate in vivo IGF-I effects on sensory pathway development by conducting anatomical studies in the S1 barrel field. Brain size, cortical area, and barrel field dimensions were increased in IGF-I and reduced in IGFBP-1 Tg mice compared with those in wild-type (wt) mice. The brain and cerebral cortex of Tg mice with the highest transgene expression were the most altered in size. Cortex and barrel field size changes were not precisely proportional, because in some Tg mice barrels were relatively more affected than the cortex, whereas in others the opposite was observed. Brain IGF-I overexpression increased the average number of neurons per barrel, neuronal cell body cross-sectional area, and barrel neuropil volume, whereas brain expression of IGFBP-1 reduced each. Neuronal density was greatly reduced in IGF-I Tg mice and increased ...Continue Reading

Citations

Aug 9, 2008·Endocrinology·A Joseph D'Ercole, Ping Ye
Jul 27, 2007·Reviews in Endocrine & Metabolic Disorders·Thomas J McDonaldPeter W Nathanielsz
Dec 17, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eckhard WolfAndreas Hoeflich
Jan 19, 2016·Neuroscience and Biobehavioral Reviews·Jesse Costales, Alexander Kolevzon
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Joëlle Dupont, Martin Holzenberger
Oct 30, 2007·Birth Defects Research. Part C, Embryo Today : Reviews·Robert D BarrettAlistair Jan Gunn
Dec 1, 1996·Molecular Neurobiology·A J D'ErcoleG Gutierrez-Ospina
Apr 22, 2009·Cell Biochemistry and Function·Ricardo José GomesMaria Alice Rostom de Mello
Oct 21, 1999·Molecular Genetics and Metabolism·L A WetterauP Cohen
Oct 3, 2002·Neuropeptides·A Joseph D'ErcoleJohn R O'Kusky

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