In vivo effects of interferon-gamma and indomethacin on murine alveolar macrophage activity

Cellular Immunology
M G StevensD P Olson

Abstract

This study determined the effects of treatment with recombinant interferon-gamma (rIFN-gamma) and the cyclooxygenase inhibitor, indomethacin (INDO), on alveolar macrophage (AM) immune function in AKR/J mice. Bactericidal activity, interleukin 1 (IL1) synthesis and antigen presentation by AM were enhanced at 24 hr after a single intravenous injection with 5 X 10(4) U of rIFN-gamma. Concomitant treatment with 2 mg INDO/kg given subcutaneously did not further enhance the effects of a single injection of rIFN-gamma, even though the prostaglandin E2 (PGE2) concentrations in lung airways were reduced by 50%. These results suggest that the stimulatory effects of rIFN-gamma on AM are not altered by blocking potentially immunosuppressive cyclooxygenase metabolites such as PGE2 with INDO. Mice given three consecutive daily intravenous injections of 5 X 10(4) U of rIFN-gamma had suppressed AM bactericidal activity and IL1 synthesis, while PGE2 concentrations in the lungs were increased. Concomitant treatment with INDO prevented suppression of these AM functions and elevation of PGE2 concentrations in the lungs. Therefore, it appears that INDO can prevent suppression of AM activity induced by multiple injections of rIFN-gamma and this effe...Continue Reading

References

Sep 3, 1985·Journal of Immunological Methods·R Peck

❮ Previous
Next ❯

Citations

Mar 11, 1991·Veterinary Immunology and Immunopathology·M G StevensP C Canning
Nov 5, 1997·American Journal of Respiratory Cell and Molecular Biology·T W WrightJ N Finkelstein
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David M AronoffMarc Peters-Golden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.