In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis

Equine Veterinary Journal
J C de GrauwP R van Weeren

Abstract

Meloxicam is a commonly used nonsteroidal anti-inflammatory drug in equine practice, but little is known about its in vivo effects on joint inflammation and cartilage turnover. To study the effects of meloxicam on biomarkers of inflammation, matrix metalloproteinase (MMP) activity, and cartilage biomarkers in joints with experimental synovitis. In a 2-period cross-over study, synovitis was induced at T = 0 h in the L or R intercarpal joint of 6 horses by intraarticular injection of 0.5 ng lipopolysaccharide (LPS). Horses received once daily meloxicam (0.6 mg/kg bwt per os) or placebo starting at post injection hour (PIH) 2, and clinical evaluations as well as blood and synovial fluid (SF) sampling were performed at PIH 0, 8, 24 and 168. Synovial fluid was analysed for prostaglandin E2, bradykinin, substance P, general MMP activity, glycosaminoglycans (GAG), CS846 epitope, type II collagen cleavage fragments (C2C) and type II collagen carboxypropeptide (CPII). Concentrations in meloxicam- vs. placebo-treated joints over time were compared using a linear mixed model. Lipopolysaccharide injection caused marked transient synovitis without systemic effects. Meloxicam caused a significant reduction in lameness at PIH 8 and 24 and ten...Continue Reading

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Citations

Jul 29, 2011·Arthritis Research & Therapy·Janny C de GrauwPaul René van Weeren
Oct 28, 2011·The Veterinary Quarterly·Janny C de Grauw
Feb 3, 2016·The Veterinary Journal·J C de Grauw, J P A M van Loon
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Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·P René van Weeren, Janny C de Grauw
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Jul 28, 2016·The Veterinary Clinics of North America. Equine Practice·Paul René van Weeren, Willem Back
Aug 25, 2016·Equine Veterinary Journal·E van de WaterD A van Doorn
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Jan 30, 2019·Australian Veterinary Journal·I G ColditzA H Small
Feb 16, 2019·Journal of Veterinary Internal Medicine·Francisco Javier MendozaAlejandro Perez-Ecija
Aug 14, 2019·PloS One·Emma Persson-SjodinMarie Rhodin
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Dec 5, 2021·Journal of Veterinary Pharmacology and Therapeutics·Marie RhodinCarl Ekstrand

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