In vivo effects of noradrenaline and noradrenergic receptor agonists and antagonists on rat cerebellar cyclic GMP levels

European Journal of Pharmacology
M HaidamousP Gonnard

Abstract

Cerebellar cyclic GMP levels can be altered by neurotransmitters and their receptor agonists and antagonists. In this study, we investigated the action of noradrenaline and certain drugs affecting alpha- and beta-adrenoceptors on rat cerebellaceptor agonists such as methoxamine and phenylephrine increased cGMP levels. alpha-Adrenoceptor antagonists such as phentolamine, phenoxybenzamine and ARC 239 decreased cGMP levels, whereas yohimbine and piperoxane which are known to act as presynaptic alpha-adrenoceptor antagonists had no effect. The action of clonidine which decreased cGMP levels at low doses was probably due to the fact that this adrenoceptor agonist inhibited the release of noradrenaline from adrenergic nerve terminals, since piperoxane injected prior to clonidine antagonized the effect of clonidine on cerebellar cGMP, and since pretreatment of the animals with 6-hydroxydopamine partially antagonized the effect of clonidine. Isoproterenol, a beta-noradrenergic agonist had no effect on cerebellar cGMP levels. Propranolol, a beta-noradrenergic antagonist decreased cGMP levels. Phenoxybenzamine or propranolol injected prior to noradrenaline decreased cerebellar cGMP.

References

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
Sep 1, 1978·Neuropharmacology·L H GreenbergB Weiss
Mar 24, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·S W GumulkaP S Schönhöfer
Feb 15, 1979·European Journal of Pharmacology·P A BrileyP Gonnard
Mar 1, 1975·The Journal of Pharmacy and Pharmacology·L FinchT J Bucher
Nov 25, 1970·Biochemical and Biophysical Research Communications·J A FerrendelliD M Kipnis
Mar 24, 1972·Biochemical and Biophysical Research Communications·J A FerrendelliD M Kipnis
Apr 1, 1974·Journal of Neurochemistry·J A FerrendelliD A Kinscherf
Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
Jan 1, 1971·European Journal of Pharmacology·P Bolme, K Fuxe
Feb 1, 1961·Acta Physiologica Scandinavica·U von EULER, F LISHAJKO

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Citations

Feb 18, 1983·European Journal of Pharmacology·G A FosterP J Roberts
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·A Fernández-GuastiC Beyer
Jan 1, 1984·General Pharmacology·C LacombeJ C Kouyoumdjian

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