PMID: 7547084Jan 1, 1994Paper

In vivo effects of recombinant human lymphotoxin on human medulloblastoma xenograft: enhancement of antitumor activity of etoposide

Biotherapy
T MikamiT Hotta

Abstract

The authors investigated the antitumor activities of rHuLT alone and in combination with etoposide on human meduloblastoma xenografts growing subcutaneously in nude mice. Intravenous administration of rHuLT (1.0 x 10(5) U/kg, 5.0 x 10(5)U/kg, 2.5 x 10(6)U/kg, three times a week for three weeks) suppressed medulloblastoma growth depending on the dose. However, the highest dosage caused serious side effects. Combining rHuLT (intravenously, 5.0 x 10(5)U/kg, three times a week for three weeks) with etoposide (intraperitoneally, 20mg/kg, once a week for three weeks) increased the antitumor activity without causing serious toxicity. Microscopically, tumor specimen showed thrombosed tumor vessels and massive necrosis 3 weeks after rHuLT treatment. Ultrastructural examination revealed that 120 minutes after the administration of rHuLT alone, disruption of interendothelial junctions was evident, and that the endothelial cells were destroyed at 240 minutes. Concentration of etoposide in tumor tissue peaked 30 minutes after intraperitoneal administration, and then decreased with time. When etoposide was administered in combination with rHuLT, the concentration of etoposide in tumor tissue after 60 to 240 minutes was significantly higher t...Continue Reading

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Citations

Feb 1, 1995·International Journal of Immunopharmacology·M IshizukaT Takeuchi
Apr 7, 1998·The American Journal of Medicine·V BarakY Shoenfeld
Jul 31, 1998·Cancer Letters·M WellerM Schabet
Jan 6, 2017·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Colleen McGrathJan Polgar
Jun 23, 2006·American Journal of Community Psychology·Shelly P Harrell, Meg A Bond

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