In vivo effects of recombinant interferon alpha A/D incorporated in gelatin microspheres on murine tumor cell growth

Japanese Journal of Cancer Research : Gann
Y TabataY Ikada

Abstract

Intraperitoneal (ip) injections of gelatin microspheres containing a very small amount of recombinant human interferon alpha A/D (A/D-IFN) (IFN-microspheres) plus free A/D-IFN improved the survival of mice bearing ascitic Meth A-R1 cells which we had isolated as IFN-resistant cells under in vitro conditions. The dose of free A/D-IFN in one injection was 10,000 IU, which was insufficient by itself for manifesting in vivo antitumor activity. In these mice, in vivo R1 cell growth was suppressed and macrophage recruitment was enhanced in comparison with mice receiving other control agents. Administration of IFN-microspheres alone was also effective but less than that of IFN-microspheres plus free A/D-IFN. Peritoneal macrophages obtained from normal or R1-bearing mice receiving ip injection of IFN-microspheres with or without free A/D-IFN were activated to inhibit the in vitro growth of R1 cells. The intratumoral injection of IFN-microspheres strongly inhibited the growth of solid R1 tumors. Intravenous injection of IFN-microspheres was effective in preventing the pulmonary metastasis of B16 melanoma cells. These results indicate that the IFN-microsphere is much more effective against tumors than free A/D-IFN.

References

Oct 15, 1977·International Journal of Cancer. Journal International Du Cancer·F R Balkwill, R T Oliver
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·H Strander, S Einhorn
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I GresserE De Maeyer
Jan 1, 1978·Cellular Immunology·R M SchultzU I Heine
Feb 15, 1978·International Journal of Cancer. Journal International Du Cancer·J R OehlerR B Herberman
Oct 1, 1985·Clinical & Experimental Metastasis·J NishimuraH Ishitsuka
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P LindahlI Gresser
Sep 15, 1972·Nature·I GresserD Brouty-Boyé
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I J FidlerZ L Barnes

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Citations

Aug 8, 2007·Cardiovascular and Interventional Radiology·Shinichi OhtaKiyoshi Murata
Jul 7, 1997·Advanced Drug Delivery Reviews·W M Saltzman, L K Fung
Dec 23, 2008·The British Journal of Radiology·S OhtaK Murata
Sep 11, 2007·European Journal of Radiology·Norihisa NittaYasuhiko Tabata
Oct 10, 2007·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Shinichi OhtaYasuhiko Tabata
Jun 11, 2010·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Emma J AlexanderAlan Horwich
Jun 17, 2014·Biological & Pharmaceutical Bulletin·Yoshitaka KanayamaYasuo Sakai
Sep 1, 1994·Cancer Immunology, Immunotherapy : CII·C M FleischmannW R Fleischmann
Dec 1, 1996·Journal of Pharmaceutical Sciences·Z Zhao, K W Leong

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