In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: a segmental perfusion study

Alimentary Pharmacology & Therapeutics
C P BearcroftM J Farthing

Abstract

5-hydroxytryptamine type 3 receptor antagonists have been shown to reduce fluid and electrolyte secretion or promote absorption in experimental models of small intestinal secretion. The aim of this study was to compare the effects of a single dose (4 mg) of the 5-hydroxytryptamine type 3 receptor antagonist alosetron and placebo on jejunal fluid and electrolyte movement in humans under basal conditions (n = 7) and following cholera toxin-induced secretion (n = 5) in a randomized, double-blind, crossover design over two separate study periods. One hour after oral alosetron or placebo, jejunal intubation was performed. A 30 cm segment of jejunum, isolated by two occluding balloons, was exposed to 15 microg of purified cholera toxin for 2 h prior to triple lumen perfusion with a plasma electrolyte solution containing [14C]-polyethylene glycol as a nonabsorbable volume marker. In the basal study, intestinal perfusion was performed without exposure to cholera toxin. Collection and analysis of the effluent from the jejunal segment allowed fluid and electrolyte movement to be calculated. Alosetron treatment increased basal jejunal fluid absorption (median 5.1 mL/cm/h [interquartile range 4.2 to 7.1] compared with placebo (3.8 [3.6 to ...Continue Reading

Citations

Oct 18, 2011·Digestive Diseases and Sciences·Michael CamilleriTyler Nelsen
Jul 27, 2001·Current Gastroenterology Reports·T Butler
May 7, 2004·Current Gastroenterology Reports·Michael J G FarthingMatthew R Banks
Jul 6, 2004·Journal of Pharmacological and Toxicological Methods·Fadi H Mourad
Aug 4, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anthony J LemboEric G Carter
Jul 19, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M J G FarthingM R Banks
Aug 3, 1999·Alimentary Pharmacology & Therapeutics·M D Gunput
Jul 9, 2002·British Journal of Clinical Pharmacology·Robin Spiller
Dec 2, 2000·Journal of Gastroenterology and Hepatology·M J Farthing
Oct 16, 2008·Natural Product Research·Mehdi BabaeiShahrokh Mousavi
Jan 30, 2013·The Journal of General Physiology·Byung-Ju JinA S Verkman
Oct 13, 2006·Current Opinion in Gastroenterology·Matthew R Banks, Michael J G Farthing
May 9, 2008·Acta Physiologica·M Berner Hansen, A-B Witte
May 16, 2006·Digestive Diseases·Michael J G Farthing
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Hirotada AkihoKazuhiko Nakamura
Jul 28, 2012·Journal of Neurogastroenterology and Motility·Robin Spiller, Ching Lam
Jan 5, 2002·Lancet·N J Talley
Jan 1, 2007·Women's Health·Lucinda A Harris, Lin Chang
Nov 4, 2000·Expert Opinion on Investigational Drugs·M Camilleri
Jun 24, 2004·Expert Opinion on Investigational Drugs·Michael J G Farthing
Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Bodil Elisabeth EngelmannMark Berner Hansen
Nov 5, 2003·Expert Opinion on Pharmacotherapy·Emeran A Mayer, Sylvie Bradesi
Jul 10, 2016·Neuropharmacology·P J KennedyG Clarke
Jan 19, 2005·The American Journal of Gastroenterology·Lin ChangEmeran A Mayer
Feb 8, 2006·Current Opinion in Gastroenterology·Lucinda A Harris, Lin Chang
Nov 18, 2003·Alimentary Pharmacology & Therapeutics·N S ColemanR C Spiller
May 10, 2003·The American Journal of Gastroenterology·Nicholas J Talley
Sep 25, 2001·The American Journal of Gastroenterology·T LemboUNKNOWN Lotronex Investigator Team
Apr 22, 2004·British Journal of Pharmacology·Michael D Crowell
Oct 29, 2000·The American Journal of Gastroenterology·D Y Kim, M Camilleri
Apr 6, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Viola Andresen, Stephan Hollerbach
Mar 9, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Richard Lea, Peter J Whorwell
Feb 9, 2010·Expert Review of Gastroenterology & Hepatology·James H Lewis
Jan 8, 2013·International Journal of Molecular Medicine·Magdy El-SalhyTrygve Hausken
Jul 4, 2003·European Journal of Gastroenterology & Hepatology·D B A Silk
Mar 26, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Danial E Baker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.