PMID: 8606395Mar 1, 1996Paper

In vivo effects of tumor necrosis factor-alpha on incised wound and gunshot wound healing

The Journal of Trauma
X FuZ Sheng

Abstract

Recombinant tumor necrosis factor alpha (TNF-alpha) was applied to incised wounds (adult rats, n = 14) and gunshot wounds (dogs, n = 5). The accumulation of RNA and DNA in regenerative tissue, the wound disruption strength (WDS), and histology were examined. The results showed that a single dose of TNF-alpha in saline with highly purified bovine serum albumin increased the WDS and accumulation of RNA and DNA in regenerative tissue in incised wounds 3 days after surgery (p < 0.05). Also, TNF-alpha promoted the inflammatory reaction in the wounded area of gunshot wounds. Histology revealed increased capillary tube-like structures and collagen formation and fibroblast proliferation in both incised and gunshot wounds treated with TNF-alpha. The results indicated that locally applied TNF-alpha benefited the incised and gunshot wound healing. These mitogenic and inflammatory effects of TNF-alpha may be the synergistic effects with other growth factors such as platelet-derived growth factor (PDGF).

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Citations

Oct 2, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wings T Y LooLouis W C Chow
Jan 6, 2007·Seminars in Arthritis and Rheumatism·Herwig PieringerGeorg Biesenbach
Sep 3, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Louis W C ChowCarter Cheng
Jan 4, 2012·Immunopharmacology and Immunotoxicology·Swapna GannabathulaRalf C Schlothauer
Jun 26, 2015·BMJ Open·Irene BraithwaiteRichard Beasley
Nov 8, 2001·Plastic and Reconstructive Surgery·V K Rumalla, G L Borah
Apr 20, 2004·The Journal of Burn Care & Rehabilitation·Philip A Efron, Lyle L Moldawer
Apr 23, 2004·Current Opinion in Rheumatology·Peter A RosandichDoyt L Conn
Jun 6, 2008·Current Opinion in Rheumatology·Dimitrios A Pappas, Jon T Giles
Sep 11, 2003·Journal of Wound Care·M S Neal
Apr 3, 1999·Journal of Wound Care·A Graham
Jan 15, 1999·Journal of Wound Care·A Graham

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