PMID: 11328773May 1, 2001Paper

In vivo efficacy of continuous infusion versus intermittent dosing of ceftazidime alone or in combination with amikacin relative to human kinetic profiles in a Pseudomonas aeruginosa rabbit endocarditis model

The Journal of Antimicrobial Chemotherapy
M A RobauxG Potel

Abstract

Ceftazidime and amikacin were administered in a Pseudomonas aeruginosa rabbit endocarditis model using computer-controlled intravenous (iv) infusion pumps to simulate human serum concentrations for the following regimens: continuous (constant rate) infusion of 4, 6 or 8 g of ceftazidime over 24 h or intermittent dosing of 2 g every 8 h either alone or in combination with amikacin (15 mg/kg once daily). The in vivo activities of these regimens were tested on four Pseudomonas aeruginosa strains. Animals were killed 24 h after the beginning of treatment. Efficacy was assessed by comparing the effects of the different groups on bacterial counts in vegetations for each strain tested. For a susceptible reference strain (ATCC 27853; MICs of ceftazidime and amikacin 1 and 2 mg/L, respectively), continuous infusion of 4 g alone or with amikacin was as effective as intermittent dosing with amikacin. For a clinical isolate producing an oxacillinase (MICs of ceftazidime and amikacin 8 and 32 mg/L, respectively), continuous infusion of 6 g was equivalent to intermittent dosing. For a clinical isolate producing a TEM-2 penicillinase (MIC of ceftazidime and amikacin 4 mg/L), continuous infusion of 6 g, but not intermittent dosing, had a signi...Continue Reading

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Citations

Jul 22, 2006·Intensive Care Medicine·Cassio GirardiUNKNOWN Experimental ICU Study Group
Jun 29, 2013·Clinical Pharmacokinetics·Tiphaine Goulenok, Bruno Fantin
Oct 22, 2013·International Journal of Antimicrobial Agents·Huawei HuangXiuming Xi
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Apr 24, 2012·Clinical and Experimental Pharmacology & Physiology·Mahipal G SinnollareddyJason A Roberts
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Evangelos J Giamarellos-BourboulisHelen Giamarellou
Nov 13, 2004·Intensive Care Medicine·Rina MehrotraMark Palazzo
Jan 25, 2005·International Journal of Antimicrobial Agents·Evangelos J Giamarellos-BourboulisHelen Giamarellou
Jul 9, 2004·The Journal of Hospital Infection·C DefezA Sotto
Jul 4, 2006·International Journal of Antimicrobial Agents·Mohammad Reza RafatiMohammad Reza Fazeli
Jun 16, 2015·The Journal of Surgical Research·George DimopoulosThomas Tsaganos
Mar 15, 2005·Scandinavian Journal of Infectious Diseases·Evangelos Giamarellos-BourboulisHelen Giamarellou
Jan 23, 2009·International Journal of Antimicrobial Agents·David BoutoilleJocelyne Caillon
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Nov 27, 2020·Frontiers in Microbiology·Kirsten J MeyerKim Lewis

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