In-vivo efficacy of hand sanitisers against feline calicivirus: a surrogate for norovirus

The Journal of Hospital Infection
S L S LagesSagar M Goyal

Abstract

Hand disinfection is considered important in preventing the transmission of viruses, including norovirus. We investigated the virucidal efficacy of nine hand sanitisers (four alcohol-based sanitisers, three non-alcoholic sanitisers and two triclosan-containing antimicrobial liquid soaps) against feline calicivirus, a surrogate for norovirus, on artificially contaminated fingertips for 30 s and 2 min contact periods. Among alcohol-based sanitisers, a product containing 99.5% ethanol was more effective than those containing 62% ethanol, 70% isopropanol or 91% isopropanol. A log(10) virus reduction factor of 1.00-1.30 was achieved with 99.5% ethanol but those containing a lower alcohol concentration only achieved a log(10) reduction factor of <or=0.67. Antiseptics containing 10% povidone-iodine (equivalent to 1% available iodine) reduced virus titre by a log(10) reduction factor of 2.67 within 30s contact time. This viral reduction rate was higher than that achieved with any of the alcohol-based sanitisers, non-alcoholic sanitisers or antimicrobial soaps. The two antimicrobial soaps tested showed minimal virus reduction (a log(10) reduction factor of 0.17-0.50), which is similar to that obtained by washing hands without any soap (...Continue Reading

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Citations

Nov 19, 2009·Foodborne Pathogens and Disease·Doris H D'Souza, Xiaowei Su
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