In vivo electromechanical assessment of heart failure patients with prolonged QRS duration

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Wilco KroonAngelo Auricchio

Abstract

Combined measurement of electrical activation and mechanical dyssynchrony in heart failure (HF) patients is scarce but may contain important mechanistic and diagnostic clues. The purpose of this study was to characterize the electromechanical (EM) coupling in HF patients with prolonged QRS duration. Ten patients with QRS width >120 ms underwent left ventricular (LV) electroanatomic contact mapping using the Noga® XP system (Biosense Webster). Recorded voltages during the cardiac cycle were converted to maps of depolarization time (TD). Electrode positions were tracked and converted into maps of time-to-peak shortening (TPS) using custom-made deformation analysis software. Correlation analysis was performed between the 2 maps to quantify EM coupling. Simulations with the CircAdapt cardiovascular system model were performed to mechanistically unravel the observed relation between TD and TPS. The delay between earliest LV electrical activation and peak shortening differed considerably between patients (TPSmin-TDmin = 360 ± 73 ms). On average, total mechanical dyssynchrony exceeded total electrical activation (ΔTPS = 177 ± 47 ms vs ΔTD = 93 ± 24 ms, P <.001), but a large interpatient variability was observed. The TD and TPS maps co...Continue Reading

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Citations

Dec 15, 2015·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·R F WiegerinckF W Prinzen
Oct 26, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Julien GrondinElisa E Konofagou
Oct 30, 2016·Pacing and Clinical Electrophysiology : PACE·Ethan BuntingElisa Konofagou
Dec 20, 2016·Future Cardiology·Konstantinos ChouchoulisDimitrios Alexopoulos
Feb 2, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Christopher PiorkowskiPhilipp Sommer
Apr 15, 2018·Circulation. Arrhythmia and Electrophysiology·Peter R HuntjensPierre Bordachar
Jun 21, 2017·Circulation. Arrhythmia and Electrophysiology·Nicolas DervalPierre Bordachar
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Jan 17, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Francesco MaffessantiAngelo Auricchio
Jul 12, 2017·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Pavel JurakPavel Leinveber
May 18, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Uyên Châu NguyênFrits W Prinzen
May 16, 2018·JACC. Clinical Electrophysiology·Angelo Auricchio, Frits W Prinzen

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