In vivo ESR measurements of free radical reactions in living mice

Toxicology Letters
H UtsumiK Takeshita

Abstract

In vivo ESR measurements were carried out to estimate free radical reactions in living mice using nitroxyl radicals as probes. The ESR signal of nitroxyl radical which was intravenously or intramuscularly injected to living female ddY mice decreased gradually by reducing to the corresponding hydroxylamine. The reduction rate was enhanced by oxidative stress, and pre-treatment of antioxidants suppressed the enhancement of signal decay. Oral administration of carbon tetrachloride enhanced signal decay in upper abdomen but not in thorax. These results indicated that free radicals, which can reduce nitroxyl radical, were produced in the upper abdomen by oral administration of carbon tetrachloride.

References

Feb 14, 1992·Biochemical and Biophysical Research Communications·Y MiuraA Hamada
Jun 14, 1991·Biochemical and Biophysical Research Communications·K TakeshitaA Hamada
Nov 15, 1990·Biochemical and Biophysical Research Communications·H UtsumiA Hamada

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Citations

May 10, 2000·Free Radical Biology & Medicine·Y Miura, T Ozawa
May 10, 2000·Free Radical Biology & Medicine·H SanoH Utsumi
May 3, 2003·Free Radical Biology & Medicine·Aki HirayamaAkio Koyama
Jun 27, 2003·Free Radical Biology & Medicine·T HerrlingN Groth
Jan 24, 2013·Journal of Clinical Biochemistry and Nutrition·Masaichi-Chang-Il Lee
Jun 4, 2004·The Journal of Investigative Dermatology·Homer S Black
Apr 6, 2005·Cancer Letters·Chandrakala Menon, Douglas L Fraker
Nov 22, 2005·Biochemical and Biophysical Research Communications·Junya UwayamaTetsuro Ishii
Dec 4, 2013·Free Radical Biology & Medicine·Shoko OkazakiKeizo Takeshita
Apr 9, 2009·Free Radical Research·Keiji YasukawaHideo Utsumi
Nov 13, 2004·American Journal of Physiology. Renal Physiology·Aki HirayamaAkio Koyama
Aug 14, 1998·Physics in Medicine and Biology·V Quaresima, M Ferrari

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