In vivo estimation of elastic heterogeneity in an infarcted human heart

Biomechanics and Modeling in Mechanobiology
Gabriel BalabanMarie E Rognes

Abstract

In myocardial infarction, muscle tissue of the heart is damaged as a result of ceased or severely impaired blood flow. Survivors have an increased risk of further complications, possibly leading to heart failure. Material properties play an important role in determining post-infarction outcome. Due to spatial variation in scarring, material properties can be expected to vary throughout the tissue of a heart after an infarction. In this study we propose a data assimilation technique that can efficiently estimate heterogeneous elastic material properties in a personalized model of cardiac mechanics. The proposed data assimilation is tested on a clinical dataset consisting of regional left ventricular strains and in vivo pressures during atrial systole from a human with a myocardial infarction. Good matches to regional strains are obtained, and simulated equi-biaxial tests are carried out to demonstrate regional heterogeneities in stress-strain relationships. A synthetic data test shows a good match of estimated versus ground truth material parameter fields in the presence of no to low levels of noise. This study is the first to apply adjoint-based data assimilation to the important problem of estimating cardiac elastic heterogene...Continue Reading

References

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Jun 1, 2012·Annals of Biomedical Engineering·J D BayerN A Trayanova
Aug 19, 2014·Computers in Biology and Medicine·Oyvind NordbøJon Olav Vik
Oct 16, 2014·Biomechanics and Modeling in Mechanobiology·Dimitri MojsejenkoJonathan F Wenk
Dec 5, 2014·IEEE Transactions on Bio-medical Engineering·Sander LandNicolas P Smith
Dec 17, 2014·Biomechanics and Modeling in Mechanobiology·Myrianthi HadjicharalambousDavid Nordsletten
Mar 24, 2016·Biomechanics and Modeling in Mechanobiology·Gabriel BalabanMarie E Rognes
May 7, 2016·Computer Methods in Biomechanics and Biomedical Engineering·Amir NikouJonathan F Wenk
Jan 1, 2017·International Journal for Numerical Methods in Biomedical Engineering·Gabriel BalabanSamuel Wall

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Citations

Apr 27, 2019·Biomechanics and Modeling in Mechanobiology·Joventino O CamposBernardo M Rocha
Feb 25, 2020·Advanced Healthcare Materials·Chenyan WangZhen Ma
Jan 13, 2021·Computers in Biology and Medicine·Sergio DempseyAbbas Samani
Oct 22, 2020·Medical Engineering & Physics·Gerardo Kenny RumindoPatrick Clarysse
Feb 20, 2021·International Journal for Numerical Methods in Biomedical Engineering·Ekaterina KovachevaAxel Loewe

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Software Mentioned

adjoint
Gmsh
PETSc SNES
EchoPac
GE
FEniCS
dolfin

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