In vivo estimation of passive biomechanical properties of human myocardium

Medical & Biological Engineering & Computing
Arnab PalitMark A Williams

Abstract

Identification of in vivo passive biomechanical properties of healthy human myocardium from regular clinical data is essential for subject-specific modelling of left ventricle (LV). In this work, myocardium was defined by Holzapfel-Ogden constitutive law. Therefore, the objectives of the study were (a) to estimate the ranges of the constitutive parameters for healthy human myocardium using non-invasive routine clinical data, and (b) to investigate the effect of geometry, LV end-diastolic pressure (EDP) and fibre orientations on estimated values. In order to avoid invasive measurements and additional scans, LV cavity volume, measured from routine MRI, and empirical pressure-normalised-volume relation (Klotz-curve) were used as clinical data. Finite element modelling, response surface method and genetic algorithm were used to inversely estimate the constitutive parameters. Due to the ill-posed nature of the inverse optimisation problem, the myocardial properties was extracted by identifying the ranges of the parameters, instead of finding unique values. Additional sensitivity studies were carried out to identify the effect of LV EDP, fibre orientation and geometry on estimated parameters. Although uniqueness of the solution canno...Continue Reading

References

Jan 1, 1977·Medical & Biological Engineering & Computing·S C Panda, R Natarajan
Feb 1, 1991·Journal of Biomechanical Engineering·J M GuccioneL K Waldman
Jul 1, 1990·The American Journal of Physiology·J D HumphreyF C Yin
Mar 1, 1986·Medical & Biological Engineering & Computing·A HorowitzE Ritman
Mar 1, 1969·Circulation Research·D D StreeterE H Sonnenblick
Jun 1, 1983·The Journal of Physiology·L L Demer, F C Yin
Mar 1, 1980·Cardiovascular Research·R M HuismanP Sipkema
Apr 1, 1994·Journal of Biomechanics·V P NovakJ D Humphrey
Jun 1, 1993·Journal of Biomechanics·J H OmensA D McCulloch
Oct 1, 1995·Journal of Biomechanics·J M GuccioneA D McCulloch
May 1, 1997·The American Journal of Physiology·J L EmeryA D McCulloch
Nov 25, 2000·Journal of Biomechanical Engineering·S DokosA A Young
Nov 25, 2000·Journal of Biomechanical Engineering·R J OkamotoJ M Guccione
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T ArtsA D McCulloch
Nov 13, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Socrates DokosIan J LeGrice
Apr 16, 2003·Journal of Biomechanics·Carey StevensPeter Hunter
Mar 30, 2004·Journal of Biomechanics·Espen W RemmeB Bjørn Angelsen
Mar 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Joseph C WalkerJulius M Guccione
Jan 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Stefan KlotzDaniel Burkhoff
Sep 26, 2006·Journal of Biomechanical Engineering·H SchmidP J Hunter
Oct 24, 2006·Journal of Biomechanics·Arun U NairFrederick J Vetter
Mar 16, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Kevin F AugensteinAlistair A Young
May 10, 2007·Biomechanics and Modeling in Mechanobiology·H SchmidP J Hunter
May 6, 2008·The Journal of Thoracic and Cardiovascular Surgery·Joseph C WalkerJulius M Guccione
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Gerhard A Holzapfel, Ray W Ogden
Aug 12, 2009·Medical Image Analysis·Vicky Y WangMartyn P Nash
Mar 25, 2011·Journal of Biomechanical Engineering·Jonathan F WenkJulius M Guccione
Aug 30, 2011·The Annals of Thoracic Surgery·Jonathan F WenkJulius M Guccione
Jan 18, 2012·Computer Methods in Biomechanics and Biomedical Engineering·Jonathan F WenkJulius M Guccione
Jan 8, 2013·International Journal for Numerical Methods in Biomedical Engineering·H M WangT J Wang
Jan 24, 2013·Medical & Biological Engineering & Computing·A de VecchiN P Smith
Jun 5, 2013·Journal of Computational Physics·Adarsh KrishnamurthyRoy Cp Kerckhoffs
Oct 1, 2014·European Journal of Mechanics. A, Solids·Brian BaillargeonEllen Kuhl
Oct 16, 2014·Biomechanics and Modeling in Mechanobiology·Dimitri MojsejenkoJonathan F Wenk
Feb 25, 2015·Annals of Biomedical Engineering·Gerhard SommerGerhard A Holzapfel

❮ Previous
Next ❯

Citations

Mar 16, 2018·Scientific Reports·Jayendra M BhalodiyaMark A Williams
Apr 5, 2019·Biomechanics and Modeling in Mechanobiology·Debao GuanHao Gao
Jun 6, 2019·Annual Review of Biomedical Engineering·Reza AvazmohammadiMichael S Sacks
May 20, 2020·Frontiers in Physiology·Wenguang LiXiaoyu Luo
Aug 30, 2019·Scientific Reports·Jayendra M BhalodiyaMark A Williams

❮ Previous
Next ❯

Software Mentioned

MSC
matic
Mimics
kern0
MATLAB
MATLAB GA
Marc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Arnab PalitMark A Williams
© 2022 Meta ULC. All rights reserved