In vivo evaluation for rhGM-CSF wound-healing efficacy in topical vehicles

Pharmaceutical Development and Technology
E MemişoğluA A Hincal

Abstract

The wound-healing efficacy of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) was studied in a mouse model. Full-thickness wounds were treated with liquid crystalline, emulsion, and niosome vehicles alone and with rhGM-CSF. The control group was non-medicated. Observation of the vehicle groups with and without the rhGM-CSF displayed better healing profiles than the control group. The vehicles were also evaluated among themselves and it was noted that emulsion base and niosome base groups gave significantly better healing profiles and histological results than the liquid crystalline base group. Among the rhGM-CSF containing groups, emulsion formulation displayed a stronger wound-healing effectiveness compared to the other formulations. In vitro release characteristics of the recombinant protein from the three vehicle formulations were demonstrated with diffusion cells. Histological and immunohistochemical evaluation was performed on biopsies taken on the last day of the experiment.

References

Jan 1, 1992·Journal of the National Medical Association·M L Walker
Apr 1, 1991·Journal of Cellular Biochemistry·G F PierceA Thomason
Apr 1, 1991·Journal of Cellular Biochemistry
Apr 1, 1991·Journal of Cellular Biochemistry·G SchultzW Clark
May 1, 1990·The Journal of Investigative Dermatology·L B Nanney
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Jul 13, 1989·The New England Journal of Medicine·G L BrownJ B Lynch
Dec 1, 1985·The Journal of Pharmacy and Pharmacology·A J BaillieA Rogerson
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WahlM B Sporn
Sep 1, 1993·The American Journal of Physiology·W R Taylor, R W Alexander
Jan 1, 1993·International Journal of Dermatology·H Hammar

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Citations

Jun 20, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic
Oct 1, 2010·Drug Delivery·Amit Kumar TiwariNarendra Kumar Jain
Oct 12, 2010·Burns : Journal of the International Society for Burn Injuries·Xinlei HuWeijie Yu
Sep 23, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Liping ZhangChunmao Han
Dec 31, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Morteza AbazariYaser Maleki

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