PMID: 8953503Oct 1, 1996Paper

In-vivo evaluation in man of a hydrophilic matrix containing propylthiouracil

The Journal of Pharmacy and Pharmacology
L KabandaJ P Remon

Abstract

To reduce the number of administrations of propylthiouracil required to treat hyperthyroidism, the bioavailability and sustained-release characteristics of 300 mg propylthiouracil formulated in hydrophilic matrix tablets were evaluated after single oral administration in healthy male volunteers. A conventional tablet was chosen as the reference formulation. For tablets formulated from three different types of hydroxypropylmethylcellulose, K15M, K4M and K100LV, propylthiouracil dissolution in-vitro was 40%, 51% and 100%, respectively, in 8 h. The three matrix formulations showed sustained plasma concentration-time profiles. The relative bioavailability was 50, 51 and 87%, respectively, for K4M, K15M and K100LV hydroxypropylmethylcellulose matrix tablets. When reverse triiodothyronine concentrations were plotted against the corresponding propylthiouracil concentrations, an antihysteresis loop was observed with the conventional tablets and the K100LV matrix tablet. A linear concentration-response curve was obtained for both the K4M and K15M formulations. The results showed that the K100LV matrix tablet gave a sustained plasma concentration-time profile and a bioavailability and extrathyroidal effect similar to that of a convention...Continue Reading

References

Jun 9, 1978·JAMA : the Journal of the American Medical Association·G Gwinup
Jan 1, 1975·The Journal of Clinical Endocrinology and Metabolism·D S Sitar, D B Hunninghake
Apr 1, 1988·Pharmaceutical Research·R C ShumakerG A Thompson
Nov 1, 1974·Acta Pharmacologica Et Toxicologica·J Kampmann, L Skovsted
Nov 1, 1981·Clinical Pharmacokinetics·J P Kampmann, J M Hansen
Nov 1, 1981·British Journal of Clinical Pharmacology·J P Kampmann, J E Mølholm Hansen
Feb 1, 1981·The Journal of Clinical Endocrinology and Metabolism·D S CooperE C Ridgway
Apr 29, 1965·The New England Journal of Medicine·M A GREERH STUDER

❮ Previous
Next ❯

Citations

Aug 29, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·George A Burdock
Aug 8, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara A WetmoreMelvin E Andersen
Jul 11, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yasunori MiyazakiKozo Takayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.