In vivo evaluation of autologous cartilage fragment-loaded scaffolds implanted into equine articular defects and compared with autologous chondrocyte implantation

The American Journal of Sports Medicine
David D FrisbieC Wayne McIlwraith

Abstract

Current autologous chondrocyte implantation (ACI) techniques require 2 surgical procedures: 1 for cell harvest and 1 for reimplantation of cultured cells. A 1-step procedure is more desirable. A 1-step surgical procedure using autologous cartilage fragments on a polydioxanone scaffold, or CAIS (cartilage autograft implantation system), in a clinically relevant defect (15-mm diameter) within equine femoral trochlea was compared with a 2-step ACI technique as well as with empty defects and defects with polydioxanone foam scaffolds alone. Controlled laboratory study. Ten skeletally mature horses were used. Articular cartilage from the lateral trochlea of the femur was harvested arthroscopically (n = 5), and chondrocytes were cultured on small intestinal submucosa to produce ACI constructs. The CAIS procedure had cartilage harvested during defect creation to prepare minced cartilage on polydioxanone-reinforced foam. The ACI and CAIS constructs were placed in defects using polydioxanone/polyglycolic acid staples. Defects were examined arthroscopically at 4, 8, and 12 months and with gross, histological, and immunohistochemical examination at 12 months. Arthroscopic, histologic, and immunohistochemistry results show superiority of bo...Continue Reading

References

Apr 1, 1990·Comprehensive Therapy·G K Miller
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Oct 1, 1996·Acta Orthopaedica Scandinavica·K Messner, J Gillquist
Oct 24, 1998·The Journal of Orthopaedic and Sports Physical Therapy·S D GilloglyT Blackburn
Feb 24, 1999·Clinics in Sports Medicine·T Minas, L Peterson
Nov 5, 1999·Clinical Orthopaedics and Related Research·M Brittberg
Jan 1, 2000·The Journal of Bone and Joint Surgery. British Volume·J B RichardsonS Roberts
May 20, 2000·Clinical Orthopaedics and Related Research·L PetersonA Lindahl
Jul 31, 2001·The American Journal of Sports Medicine·T MuellnerL Engebretsen
Oct 18, 2001·Clinical Orthopaedics and Related Research·M BrittbergL Peterson
Dec 26, 2001·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·L J MicheliD Zurakowski
Jan 19, 2002·The American Journal of Sports Medicine·Lars PetersonAnders Lindahl
May 16, 2002·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·M MarcacciI Loreti
Jan 18, 2003·Journal of Cellular Biochemistry·Daniel WuDaniel A Grande
Feb 5, 2003·Clinical Orthopaedics and Related Research·David D FrisbieC Wayne McIlwraith
May 2, 2003·The Journal of Bone and Joint Surgery. American Volume·Lars PetersonAnders Lindahl
Mar 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Gunnar KnutsenOddmund Johansen
Apr 5, 2005·Clinical Orthopaedics and Related Research·Anna I VasaraIlkka Kiviranta
Mar 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Jennifer J WoodTimothy R Coté
May 3, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yiling LuFrancois Binette
Jul 13, 2006·The American Journal of Sports Medicine·David D FrisbieC Wayne McIlwraith

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Citations

Nov 10, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A H GomollM Marcacci
Feb 22, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A MarmottiG M Peretti
Nov 13, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A MarmottiG M Peretti
Jan 12, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Giuseppe FilardoElizaveta Kon
Jan 18, 2013·Arthritis·Martin H GregorySeth L Sherman
Nov 30, 2013·International Orthopaedics·Ning WangGian M Salzmann
Aug 28, 2014·BMC Veterinary Research·Edivaldo A N MartinsLuis C L C Silva
Nov 14, 2015·Annual Review of Animal Biosciences·Toshihiko EzashiR Michael Roberts
Jul 24, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Marc TompkinsCree M Gaskin
Mar 8, 2013·Foot and Ankle Clinics·Rachel Triche, Bert R Mandelbaum
Nov 9, 2010·Foot and Ankle Clinics·Saadiq F El-AminCato T Laurencin
Sep 1, 2015·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Davide Edoardo BonasiaRoberto Rossi
Jul 3, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zhu DaiWenjun Ding
Dec 5, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kolja GelseGötz H Welsch
May 1, 2016·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Chi ZhangXiang-Jin Lin
May 21, 2016·Journal of Tissue Engineering and Regenerative Medicine·J David StackFlorent David
Aug 11, 2011·The American Journal of Sports Medicine·Davide Edoardo BonasiaAnnunziato Amendola
Mar 16, 2017·Arthritis & Rheumatology·Luiz Felipe AmbraAndreas H Gomoll
Dec 16, 2009·The American Journal of Sports Medicine·Allen F Anderson, Margaret Smith
Jun 4, 2011·The American Journal of Sports Medicine·Bruce Reider
Mar 22, 2018·Connective Tissue Research·Eve SaloniusIlkka Kiviranta
Jun 21, 2017·Sports Health·Philip J YorkArmando F Vidal
Aug 24, 2017·Hand : Official Journal of the American Association for Hand Surgery·Daniel E HessD Nicole Deal
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
Jan 15, 2019·Tissue Engineering. Part B, Reviews·Sarah I M LepageThomas G Koch
Feb 26, 2016·Journal of Experimental Orthopaedics·Conor J MoranTanya J Levingstone
May 6, 2011·Expert Review of Medical Devices·D Alex StrohMichael A Mont
Jun 18, 2019·The American Journal of Sports Medicine·Ryosuke MatsushitaNobuo Adachi
Apr 24, 2013·Bone & Joint Research·C W McIlwraithC E Kawcak
Jan 17, 2015·Current Reviews in Musculoskeletal Medicine·Adam B Yanke, Susan Chubinskaya
May 29, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rachel C StewartMark W Grinstaff
Feb 14, 2020·Cartilage·Bjørn Borsøe ChristensenMartin Lind
Jan 21, 2020·Equine Veterinary Journal·Maria C Fugazzola, Paul R van Weeren
Feb 25, 2020·Expert Review of Medical Devices·Colleen M WixtedSamuel B Adams
Aug 1, 2015·Sports Medicine and Arthroscopy Review·Adam B YankeBrian J Cole
Sep 12, 2017·The American Journal of Sports Medicine·Chin-Chean WongTsung-Lin Yang
Oct 1, 2011·Cartilage·C Wayne McIlwraithAlan J Nixon

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Methods Mentioned

BETA
biopsy

Software Mentioned

SAS

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