PMID: 6640048Oct 1, 1983Paper

In vivo evaluation of ocular inserts of hydrogel impregnated with antibiotics for trachoma therapy

Biomaterials
S HosakaR L Nichols

Abstract

Sustained release of antibiotics from hydrogel matrices in the eye was studied for the purpose of developing a new method for trachoma therapy. Copolymers of N-vinylpyrrolidone were moulded into an ocular insert and impregnated with erythromycin or erythromycin estolate. The antibiotic-hydrogel inserts completely suppressed the chlamydia trachomatis infection in the owl monkey eyes. The drug elution rates were a little lower in vivo than in vitro. By comparison of the drug elution rate in the human eye with that in the owl monkey eye, similar therapeutic effect is expected in the treatment of human trachoma.

Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·R GurnyV Baeyens
Nov 16, 2010·Drug Development and Industrial Pharmacy·Dharmendra JainRinti Banerjee
Jan 1, 1989·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·B JansenG Pulverer
Mar 31, 2009·Expert Opinion on Drug Delivery·Thirumurthy Velpandian
Jul 1, 1991·Journal of Biomaterials Applications·S DumitriuD Dumitriu
Jan 19, 2018·Pharmaceutics·Marion DubaldHatem Fessi

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