In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient.

Virology
Matthew J MemoliJeffery K Taubenberger

Abstract

The influenza A(H1N1)pdm09 virus has circulated worldwide and continued to cause complicated infections and deaths. Reports have identified an increased prevalence of the hemagglutinin receptor binding domain D222G mutation in viruses isolated from individuals who have suffered such severe infections, but this association is still unclear. Virus isolated from a nasopharyngeal wash of a severely ill immunocompromised patient at the time of diagnosis contained the D222, but isolates collected later in his course from a bronchoalveolar lavage contained primarily the G222 mutation and was mixed with a minor population of D222. These clinical isolates were compared to a G222 plaque purified virus in the ferret model. The G222 predominant clinical isolate was the most pathogenic in ferrets and developed the most diversity at the 222 amino acid position during infection, suggesting that increased diversity and not a specific polymorphism at HA 222 may be important in predicting pathogenic potential.

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Citations

Nov 5, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew J MemoliJeffery K Taubenberger
Oct 25, 2016·PloS One·T IlyichevaA Ryzhikov
Jul 26, 2019·Science Translational Medicine·Jeffery K TaubenbergerDavid M Morens
Feb 27, 2021·PLoS Pathogens·Katarina M BraunThomas C Friedrich
May 30, 2021·Emerging Microbes & Infections·Xi JiangMichael A Kennedy
Dec 31, 2020·ACS Central Science·Nico J OvereemJurriaan Huskens

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