In Vivo Evaluation of Withania somnifera-Based Indian Traditional Formulation ( Amukkara Choornam), Against Chikungunya Virus-Induced Morbidity and Arthralgia

Journal of Evidence-based Integrative Medicine
Jaspreet JainSujatha Sunil

Abstract

Chikungunya viral fever results in extreme morbidity and arthralgia in affected individuals. Currently, modern medicines providing symptomatic relief for the acute febrile phase and the chronic arthritic phase are only options available. Traditional Indian medical system, however, uses specific formulations for treatment of this infection; one such polyherbal formulation used to treat the postpyretic phase of chikungunya is amukkara choornam. The current study was undertaken to study the efficacy of amukkara choornam in the treatment of chikungunya in C57BL/6J mice. The formulation when administered to chikungunya-infected mice relieved morbidity and joint swelling. Analysis of virus clearance in brain and joint tissues on formulation treatment revealed a direct correlation of viral load in brain to morbidity during infection; likewise, joint swelling receded prior to complete viral clearance explaining possible immunomodulatory effect of amukkara choornam. This study provides insight into the possible mode of action of amukkara choornam during chikungunya.

References

Apr 15, 2003·Journal of Virology·Susan H Cook, Diane E Griffin
Nov 8, 2005·Journal of Ethnopharmacology·Pulok K Mukherjee, Atul Wahile
Jul 3, 2007·PLoS Pathogens·Marion SourisseauOlivier Schwartz
May 6, 2008·Tropical Doctor·Manisha JainAnita Chakravarti
Jul 16, 2008·Vector Borne and Zoonotic Diseases·Xavier De LamballerieRoger Le Grand
Aug 12, 2008·Vaccine·Eryu WangScott C Weaver
Jul 31, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Babasaheb V TandaleAkhilesh C Mishra
Aug 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Erin StaplesAnn M Powers
Jan 1, 2008·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·N S JeganathanHannah R Vasanthi
May 4, 2010·PLoS Neglected Tropical Diseases·Michelle M ThiboutotKaruppiah Muthumani
Jun 4, 2010·Journal of Virology·Joy GardnerAndreas Suhrbier
May 9, 2012·Nature Reviews. Rheumatology·Andreas SuhrbierPhilippe Gasque
Apr 5, 2013·PLoS Neglected Tropical Diseases·Clémentine SchilteAlain Michault
Jan 25, 2014·Phytotherapy Research : PTR·Shaiju K VareedMuraleedharan G Nair
Sep 1, 2016·Antiviral Research·Szu-Cheng KuoChang-Chi Lin
Apr 6, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jaspreet JainSujatha Sunil

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Citations

Jul 10, 2020·Journal of Biomolecular Structure & Dynamics·Manish Kumar TripathiPunit Kaur
Sep 12, 2020·Pharmaceuticals·Alexander Panossian, Thomas Brendler
Aug 7, 2021·Journal of Biomolecular Structure & Dynamics·Meenakshi Chaudhary, Deepak Sehgal

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