In vivo evidence for GABAergic control of serotonin release in the cat substantia nigra

European Journal of Pharmacology
P SoubriéJ Glowinski

Abstract

Push-pull cannulae were used for estimating the release of endogenously synthesized [3H]serotonin in both substantia nigra and caudate nuclei of halothane-anaesthetized cats. The unilateral nigral application of GABA (10-5 M) reduced the local release of [3H]serotonin picrotoxin induced an opposite effect. Both treatments failed to modify [3H]serotonin release in the caudate nuclei or in the contralateral substantia nigra. These results suggest that GABAergic neurons innervating the substantia nigra may regulate nigral serotonin transmission. The possibility that such a regulation could be presynaptic (direct or through other nigral neurotransmitters) or related to a change in the activity of the nigro-raphe projection is discussed.

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·J Arnt, J Scheel-Krüger

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Citations

Nov 12, 1986·European Journal of Pharmacology·B SchneiderT Unger
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·T P BlackburnT F Lee
Sep 1, 1992·Brain Research. Brain Research Reviews·J W Wright, J W Harding
May 14, 1998·Neuroscience and Biobehavioral Reviews·R D MyersM F Lankford
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J S Hutchinson, J Y Chan
Jan 1, 1990·The Korean Journal of Internal Medicine·D Y LimS P Hong

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