In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus.

Investigative Ophthalmology & Visual Science
Henrik Holvin JacobsenPer Kristian Eide

Abstract

Impaired ability to remove toxic metabolites from central nervous system may be an important link between cerebral and ophthalmic degenerative diseases. The aim of the present study was to compare the glymphatic function in the visual pathway in patients with idiopathic normal pressure hydrocephalus (iNPH), a neurodegenerative dementia subtype, with a reference group. We compared 31 subjects with Definite iNPH (i.e., shunt-responsive) with 13 references in a prospective and observational study. After intrathecal injection of the magnetic contrast agent gadobutrol (Gadovist, 0.5 mL, 1.0 mmol/mL, Bayer Pharma AG), serving as a tracer, consecutive magnetic resonance imaging (MRI) scans were obtained (next 24-48 hours). The normalized MRI T1 signal recorded in the cerebrospinal fluid (CSF) and along the visual pathway served as a semi-quantitative measure of tracer enrichment. Gadobutrol does not penetrate the blood-brain barrier and is thus confined to the extravascular space. Overnight measurements of pulsatile intracranial pressure were used as a surrogate marker for the intracranial compliance. The tracer enriched the prechiasmatic cistern similarly in both groups, but clearance was delayed in the iNPH group. Moreover, both del...Continue Reading

References

Jan 22, 2008·Acta Neurologica Scandinavica·A Brean, P K Eide
Mar 20, 2009·Journal of Glaucoma·Ta C Chang, Kuldev Singh
Nov 28, 2012·Neurologia Medico-chirurgica·Etsuro MoriUNKNOWN Japanese Society of Normal Pressure Hydrocephalus
Feb 1, 2013·Investigative Ophthalmology & Visual Science·Jeremy M Sivak
Feb 26, 2013·The Journal of Clinical Investigation·Jeffrey J IliffHelene Benveniste
Nov 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey J IliffMaiken Nedergaard
Sep 11, 2014·Annals of Neurology·Benjamin T KressMaiken Nedergaard
Dec 5, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey J IliffMaiken Nedergaard
May 8, 2015·Neurochemical Research·Nadia Aalling JessenMaiken Nedergaard
Jun 17, 2015·The Journal of Experimental Medicine·Aleksanteri AspelundKari Alitalo
Jun 19, 2015·Investigative Ophthalmology & Visual Science·Alastair K Denniston, Pearse A Keane
Jun 30, 2015·Fluids and Barriers of the CNS·Peter WostynVeva De Groot
Aug 22, 2016·Acta Neuropathologica·Benjamin Michael DavisMaria Francesca Cordeiro
Feb 15, 2017·Investigative Ophthalmology & Visual Science·Alastair K DennistonSusan P Mollan
Sep 2, 2017·The Journal of Clinical Investigation·Antoine LouveauJonathan Kipnis
Oct 4, 2017·Brain : a Journal of Neurology·Geir RingstadPer Kristian Eide
Oct 4, 2017·Investigative Ophthalmology & Visual Science·Emily MathieuYeni H Yücel
Nov 18, 2017·Journal of Neurosurgery·Pasquale GallinaBerardino Porfirio
Jul 13, 2018·JCI Insight·Geir RingstadPer K Eide
Jul 27, 2018·Nature·Sandro Da MesquitaJonathan Kipnis
Nov 20, 2018·Nature Communications·Humberto MestreDouglas H Kelley
Dec 14, 2018·Investigative Ophthalmology & Visual Science·Emily MathieuYeni H Yücel
Dec 19, 2018·ELife·Humberto MestreMaiken Nedergaard
Jun 28, 2019·Investigative Ophthalmology & Visual Science·Henrik Holvin JacobsenPer Kristian Eide
Jul 10, 2019·Dementia & Neuropsychologia·Louise Makarem OliveiraGustavo C Román
Jul 20, 2019·AJNR. American Journal of Neuroradiology·C S EdeklevP K Eide
Mar 28, 2020·Science Translational Medicine·Xiaowei WangMaiken Nedergaard
May 8, 2020·Fluids and Barriers of the CNS·Karen Brastad Evensen, Per Kristian Eide

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Methods Mentioned

BETA
X-ray
biopsy

Software Mentioned

Sectra Picture Archiving and Communication System ( IDS7
Stata
SPSS
SE

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