In vivo evidence for the reversible action of the monoamine oxidase inhibitor brofaromine on 5-hydroxytryptamine release in rat brain

Naunyn-Schmiedeberg's Archives of Pharmacology
N Bel, F Artigas

Abstract

We have used intracerebral microdialysis to examine the reversibility of the action of brofaromine, a selective inhibitor of monoamine oxidase-A (MAO, E.C. 1.4.3.4.), on 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) output in rat frontal cortex. Brofaromine significantly increased the 5-HT output to about 200% of basal values 4 h after the s.c. administration of 10 and 30 mg/kg (but not 3 mg/kg) and reduced the concentration of 5-HIAA in the dialysate dose-dependently (61%, 53% and 41% of basal value with doses of 3, 10 and 30 mg/kg, respectively). At this time, cortical 5-HT concentration was increased and cortical 5-HIAA concentration was decreased in a dose-dependent manner. Treatment of rats with 10 mg/kg brofaromine plus 2.5 mg/kg of the irreversible MAO-B inhibitor L-deprenyl increased the concentration of 5-HT in the dialysate more than did brofaromine alone (503% vs 206% of the basal value, 4h after administration). Similarly, clorgyline (5 mg/kg) plus L-deprenyl (2.5 mg/kg) increased the concentration of 5-HT in the dialysate to 461% of the control value. This indicates that the concurrent inhibition of both types of MAO increases 5-HT output more than the selective blockade of either enzyme subtyp...Continue Reading

Citations

May 26, 2005·Neurobiology of Aging·Marie-Eve TremblayFrancesca Cicchetti
Oct 21, 2000·European Journal of Pharmacology·Y MakiT Koyama
Nov 26, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Gerardy, A Dresse
Aug 1, 1997·The European Journal of Neuroscience·N BalF Artigas
May 12, 2010·Basic & Clinical Pharmacology & Toxicology·Swapna KrishnamoorthyRui Tao

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