In vivo evidence for the role of lipoprotein lipase activity in the regulation of apolipoprotein AI metabolism: a kinetic study in control subjects and patients with type II diabetes mellitus

The Journal of Clinical Endocrinology and Metabolism
R FrénaisM Krempf

Abstract

The aim of this study was to delineate the role of lipoprotein lipase (LPL) activity in the kinetic alterations of high density lipoprotein (HDL) metabolism in patients with type II diabetes mellitus compared with controls. The kinetics of HDL were studied by endogenous labeling of HDL apolipoprotein AI (HDL-apo AI) using a primed infusion of D(3)-leucine. The HDL-apo AI fractional catabolic rate (FCR) was significantly increased (0.32 +/- 0.07 vs. 0.23 +/- 0.05 pool/day; P < 0.01), and HDL composition was changed [HDL cholesterol, 0.77 +/- 0.16 vs. 1.19 +/- 0.37 mmol/L (P < 0.05); HDL triglycerides, 0.19 +/- 0.12 vs. 0.10 +/- 0.03 mmol/L (P < 0.05)] in diabetic patients compared with healthy subjects. HDL-apo AI FCR was correlated to plasma and HDL triglyceride concentrations (r = 0.82; P < 0.05 and r = 0.80; P < 0.05, respectively) and to homeostasis model assessment (r = 0.78; P < 0.05). Postheparin plasma LPL activity was decreased in type II diabetes (6.8 +/- 2.8 vs. 18.1 +/- 5.2 micromol/mL postheparin plasma.h; P < 0.005) compared with that in healthy subjects and was correlated to the FCR of HDL-apo AI (r = -0.63; P < 0.05). LPL activity was also correlated with HDL cholesterol (r = 0.78; P < 0.05), plasma and HDL trigl...Continue Reading

Citations

Jun 5, 2003·Journal of Lipid Research·Marian C CheungJohn D Brunzell
Jan 27, 2009·Journal of Lipid Research·Bruno VergèsLaurence Duvillard
Nov 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Esther M M OoiP Hugh R Barrett
Nov 25, 2004·Best Practice & Research. Clinical Gastroenterology·Xavier Formiguera, Ana Cantón
Dec 7, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Enzo BonoraUNKNOWN Group of Italian Scientists of Insulin Resistance (GISIR)
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K Bach-NgohouJ M Bard

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